定量组织速度成像对家兔肺动脉栓塞模型的动态观察

发布时间：2019-05-29 06:05

【摘要】：目的评价定量组织速度成像技术对检测家兔肺动脉栓塞模型右室功能的应用价值。方法家兔22只,经耳缘静脉注入栓子制成急性肺动脉栓塞模型。分别于造模前、造模后即刻、造模后1周及3周观察家兔右心室动态变化情况。存储心尖四腔心切面定量组织速度成像(QTVI)图像并进行脱机分析。结果造模后即刻,右室游离壁基底段,中间段的收缩期峰值速度(VP)均较造模前明显减低,达峰时间(TVp)延长,三尖瓣口舒张早期峰值血流速度/舒张晚期峰值血流速度(Ve/Va)大于1。差别具有显著性意义(P0.05)。造模后1周,右室游离壁基底段,中间段的收缩期峰值速度(VP)均较造模前减低,达峰时间(TVp)延长,较造模后即刻组差别无显著性意义,但Ve/Va小于1。造模后3周,右室游离壁基底段,中间段的收缩期峰值速度(VP)较造模前仍减低,Ve/Va比值小于1。较造模后1周组差别具有显著性意义(P0.05)。组内比较收缩期峰值速度,右室游离壁基底段均较中间段增大,差别具有显著性意义。但收缩期达峰时间,两者差别无显著性意义。结论定量组织速度成像能够直观反映家兔右室舒张及收缩功能状况,是评价动物肺动脉栓塞模型右室功能的重要手段。
[Abstract]:Objective to evaluate the value of quantitative tissue velocity imaging in detecting right ventricular function in rabbits with pulmonary embolism. Methods Acute pulmonary embolism model was established in 22 rabbits by injecting thrombus into ear margin vein. The dynamic changes of right ventricle in rabbits were observed before, immediately after modeling, 1 week and 3 weeks after modeling. The quantitative tissue velocity imaging (QTVI) images of apical four-chamber heart section were stored and analyzed offline. Results immediately after modeling, the peak systolic velocity (VP) in the basal segment and middle segment of the right ventricular free wall was significantly lower than that before modeling, and the peak time (TVp) was prolonged. The early diastolic peak flow velocity / late diastolic peak flow velocity (Ve/Va) of tricuspid orifice was greater than 1. The difference was significant (P 0.05). One week after modeling, the peak systolic velocity (VP) in the basal segment and middle segment of the right ventricular free wall was lower than that before the model, and the peak time (TVp) was prolonged, which was not significantly different from that in the immediate group, but the Ve/Va was less than 1. 5%. Three weeks after modeling, the peak systolic velocity (VP) in the basal segment of the right ventricular free wall and the middle segment was still lower than that before the modeling, and the ratio of Ve/Va was less than 1. 5%. There was significant difference between the two groups one week after modeling (P 0.05). The peak systolic velocity and the basal segment of the right ventricular free wall in the group were significantly higher than those in the middle segment, and the difference was significant. However, there was no significant difference in systolic peak time between the two groups. Conclusion quantitative tissue velocity imaging can directly reflect the relaxation and systolic function of right ventricle in rabbits, and it is an important method to evaluate the function of right ventricle in animal pulmonary embolism model.
【作者单位】：深圳市罗湖区人民医院超声科;深圳市中医院超声科;
【分类号】：R563.5;R-332

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