白介素33对慢性支气管炎患者呼吸道分泌物清除的影响

发布时间：2019-05-30 01:50

【摘要】：目的研究白介素33(IL-33)对于慢性支气管炎患者呼吸道分泌物清除的影响,并对患者症状的影响进行探讨。方法选取2014年4月-2016年4月在医院进行治疗的慢性支气管炎患者90例为观察组,健康志愿者60名为对照组,对其血清IL-33表达量进行检测,慢性支气管炎患者以均值为界,将观察组患者分为高表达与低表达组,对两组患者呼吸道分泌物清除能力进行评估。结果 IL-33在慢性支气管炎患者的表达明显高于健康志愿者;在IL-33高表达的慢性支气管炎患者中,右肺在20、40、60、80、120min的保留率均小于低表达患者,在右肺的外周区域中高表达IL-33的清除率也始终低于低表达IL-33组,IL-33的表达对左肺的影响稍弱,整体上仅有20与40min处差异有统计学意义(P0.05),而IL-33对于左肺中心区域的影响则稍大,在20、40、60min处差异均有统计学意义(P0.05)。结论 IL-33在慢性支气管炎患者中高表达,但对慢性支气管炎的症状无影响,同时IL-33能够明显影响患者右肺呼吸道分泌物的清除,对于左肺呼吸道分泌物的清除则稍弱。
[Abstract]:Objective to study the effect of interleukin 33 (IL-33) on respiratory tract secretion clearance in patients with chronic bronchitis and to explore the effect of IL 33 (IL 33) on respiratory secretion clearance in patients with chronic bronchitis. Methods 90 patients with chronic bronchitis treated in hospital from April 2014 to April 2016 were selected as observation group and 60 healthy volunteers as control group. The expression of serum IL-33 was detected in patients with chronic bronchitis. The patients in the observation group were divided into high expression group and low expression group, and the clearance ability of respiratory secretions in the two groups was evaluated. Results the expression of IL-33 in patients with chronic bronchitis was significantly higher than that in healthy volunteers. In patients with chronic bronchitis with high expression of IL-33, the retention rate of right lung at 20, 40, 60, 80120 min was lower than that of patients with low expression of IL-33, and the clearance rate of high expression of IL-33 in the peripheral area of right lung was always lower than that of low expression IL-33 group. The effect of IL-33 expression on the left lung was slightly weaker, only 20 and 40min were significantly different as a whole (P 0.05), while IL-33 had a slightly greater effect on the central area of the left lung, and the difference was statistically significant at 20, 40 and 60 min (P 0.05). Conclusion the expression of IL-33 is high in patients with chronic bronchitis, but it has no effect on the symptoms of chronic bronchitis. At the same time, IL-33 can significantly affect the clearance of right pulmonary respiratory tract secretions, but the clearance of left pulmonary respiratory secretions is slightly weaker.
【作者单位】：安徽医科大学呼吸内科系;安徽医科大学第一附属医院呼吸内科;
【分类号】：R562.21

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