合并骨侵蚀及间质性肺病的类风湿关节炎患者血清IL-25水平升高
发布时间：2019-06-21 02:27
【摘要】：目的分析类风湿关节炎(RA)患者疾病发展进程中血清白细胞介素25(IL-25)和IL-17水平以及与骨侵蚀及合并间质性肺病(ILD)的关系。方法 ELISA检测117例RA患者和56例健康对照血清IL-25和IL-17水平;检测血沉(ESR)、C反应蛋白(CRP)、类风湿因子(RF)、抗环瓜氨酸(CCP)抗体水平;胸部高分辨率CT(HR-CT)诊断ILD;肌骨超声检查判断骨侵蚀情况;Sharp评分划分影像学等级;VAS评分和28个关节疾病活动度评分(DAS28)反映RA患者的疾病活动情况。比较各组之间IL-25和IL-17的水平差异并分析相关性。结果 RA组的IL-25和IL-17水平明显高于健康对照组,有骨侵蚀的RA患者IL-25水平显著高于无骨侵蚀的RA患者。有ILD的RA患者IL-25水平显著高于不伴有ILD的RA患者。IL-25水平与RF-IgG、RF-IgA和RF-IgM均呈正相关(r=0.285、0.314、0.380),同时,IL-17水平与RF-IgG和RF-IgM呈正相关(r=0.198、0.273),但二者与抗CCP抗体之间无相关性。结论合并骨侵蚀及间质性肺病的类风湿关节炎患者血清IL-25水平升高。
[Abstract]:Objective to analyze the relationship between serum IL-25 (IL-25) and IL-17 levels and bone erosion and (ILD) in patients with rheumatoid arthritis (RA). Methods ELISA was used to detect serum IL-25 and IL-17 levels in 117 patients with RA and 56 healthy controls, erythrocyte sedimentation rate (ESR), C reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrulline (CCP) antibody level, chest high resolution CT (HR-CT) to diagnose ILD; muscle bone ultrasound to judge bone erosion, Sharp score to classify imaging grade. VAS score and 28 joint disease activity score (DAS28) reflected the disease activity of RA patients. The differences of IL-25 and IL-17 levels among the three groups were compared and the correlation was analyzed. Results the levels of IL-25 and IL-17 in RA group were significantly higher than those in healthy control group, and the IL-25 levels in RA patients with bone erosion were significantly higher than those in RA patients without bone erosion. The level of IL-25 in RA patients with ILD was significantly higher than that in RA patients without ILD. Il-25 levels were positively correlated with RF-IgG,RF-IgA and RF-IgM (r 鈮，
本文编号：2503713
[Abstract]:Objective to analyze the relationship between serum IL-25 (IL-25) and IL-17 levels and bone erosion and (ILD) in patients with rheumatoid arthritis (RA). Methods ELISA was used to detect serum IL-25 and IL-17 levels in 117 patients with RA and 56 healthy controls, erythrocyte sedimentation rate (ESR), C reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrulline (CCP) antibody level, chest high resolution CT (HR-CT) to diagnose ILD; muscle bone ultrasound to judge bone erosion, Sharp score to classify imaging grade. VAS score and 28 joint disease activity score (DAS28) reflected the disease activity of RA patients. The differences of IL-25 and IL-17 levels among the three groups were compared and the correlation was analyzed. Results the levels of IL-25 and IL-17 in RA group were significantly higher than those in healthy control group, and the IL-25 levels in RA patients with bone erosion were significantly higher than those in RA patients without bone erosion. The level of IL-25 in RA patients with ILD was significantly higher than that in RA patients without ILD. Il-25 levels were positively correlated with RF-IgG,RF-IgA and RF-IgM (r 鈮，
本文编号：2503713
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