胸腺肽α1联合乌体林斯对慢性阻塞性肺疾病急性加重的预防作用

发布时间：2019-06-21 15:26

【摘要】：目的探讨胸腺肽α1联合乌体林斯对慢性阻塞性肺疾病(COPD)患者急性加重期的预防作用。方法将120例稳定期COPD患者随机分为治疗组和对照组,每组各60例。两组均给予抗生素、化痰、氧疗、平喘、解痉、并纠正电解质紊乱等常规治疗。治疗组在常规治疗的基础上接受皮下注射胸腺肽和深部肌肉注射乌体林斯,对照组仅使用常规方法治疗,观察两组临床效果和不良反应,两组均跟踪观察1年,每2周电话随访1次,并于治疗后3、6、9及12个月进行肺功能检查,观察咳嗽、咳痰和喘息等临床症状,记录肺功能FVC、FEV1及免疫球蛋白的变化。结果治疗组患者临床症状得到明显改善,在治疗后的3、6、9及12个月的检查中,治疗组患者再次发生急性加重的间隔时间比对照组的明显延长,发生急性加重次数明显减少(P0.05)。结论胸腺肽α1联合乌体林斯对COPD急性加重有较好的预防作用,能有效地降低了患者急性加重的频率。
[Abstract]:Objective To study the preventive effect of thymosin-1 combined with Utilin on acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods 120 patients with stable COPD were randomly divided into treatment group and control group. The two groups were given antibiotics, expectorant, oxygen therapy, antiasthmatic, spasmolytic, and corrected the general treatment of electrolyte disturbance. On the basis of routine treatment, the treatment group received the subcutaneous injection of the thymosin and the deep intramuscular injection of Utilin, and the control group only used the conventional method to treat and observe the clinical effects and adverse reactions of the two groups. The two groups were followed up for 1 year and the telephone was followed up for 1 time every two weeks. The lung function was examined at 3,6,9 and 12 months after treatment, and the clinical symptoms such as cough, expectoration and wheezing were observed, and the changes of FVC, FEV1 and immunoglobulin were recorded. Results The clinical symptoms of the treatment group were significantly improved. In the 3,6,9 and 12 months after treatment, the time between the patients in the treatment group and the acute exacerbation was significantly longer than that of the control group, and the number of acute exacerbations was significantly decreased (P0.05). Conclusion The combination of thymosin 1 and Utilin has a better preventive effect on acute exacerbation of COPD, and the frequency of acute exacerbation of COPD can be effectively reduced.
【作者单位】：梧州市工人医院呼吸科;
【分类号】：R563.9

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