不同部位起搏对正常和心力衰竭犬心室跨壁复极梯度的影响(英文)
发布时间:2021-11-03 07:55
跨壁复极梯度的改变可能导致跨壁复极离散度的增加和室速的增多,跨壁复极离散可能在左室心外膜起搏相关猝死中发生重要作用。本研究对心力衰竭(心衰)犬进行心室不同部位起搏,观察左心室跨壁复极梯度的变化。选用8条健康杂种犬,随机分成健康对照组和心衰组(n=4),心衰组4条健康犬经快速右心室心内膜心尖部(right ventricular apical endocardium,RVEndo)起搏4~5周建立慢性充血性心衰模型。健康对照组和心衰组分别在右心房(right atrium, RA)起搏、RVEndo起搏、左心室心外膜(left ventricular lateral epicardium, LVEpi)起搏及双心室(biventricular, Biv)同步起搏的条件下,应用自制的跨室壁单相动作电位(monophasic action potential, MAP)记录电极,于左心室同步记录和测量三层心肌(内层、中层、外层)的MAP时程(MAP duration, MAPD)。结果显示,健康对照组窦性心律时左心室三层心肌M...
【文章来源】:生理学报. 2020,72(04)北大核心CSCD
【文章页数】:7 页
【文章目录】:
1 MATERIALS AND METHODS
1.1 Animal preparation
1.2 Electrodes for recording ventricular repolarization
1.3 Experimental protocol
1.4 MAPD analysis
1.5 Statistical analysis
2 RESULTS
2.1 The transmural MAPD in the healthy group
2.2 The transmural MAPD in the HF group
3 DISCUSSION
本文编号:3473326
【文章来源】:生理学报. 2020,72(04)北大核心CSCD
【文章页数】:7 页
【文章目录】:
1 MATERIALS AND METHODS
1.1 Animal preparation
1.2 Electrodes for recording ventricular repolarization
1.3 Experimental protocol
1.4 MAPD analysis
1.5 Statistical analysis
2 RESULTS
2.1 The transmural MAPD in the healthy group
2.2 The transmural MAPD in the HF group
3 DISCUSSION
本文编号:3473326
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