肾嫌色细胞癌113例的临床特征和预后相关因素分析

发布时间：2017-12-28 22:09

本文关键词：肾嫌色细胞癌113例的临床特征和预后相关因素分析　出处：《上海医学》2015年07期 　论文类型：期刊论文

【摘要】：目的分析单中心肾嫌色细胞癌的临床特征,探讨与肾嫌色细胞癌预后相关的临床指标。方法通过回顾性分析2005年1月—2015年5月在上海长海医院住院手术,且经术后病理学检查证实为肾嫌色细胞癌的113例患者的临床、病理和随访资料。研究终点为总生存期,生存分析数据采用Kaplan-Meier法进行计算,并用Log-rank法对生存率进行分析比较。结果肾嫌色细胞癌占同期所有肾细胞癌的4.8%(113/2 355),患者中位年龄为50.96岁,男女比例为1.01∶1,80例(70.8%)无症状。肾嫌色细胞癌的1、3、5年生存率分别为98.2%(108/110)、96.4%(106/110)、95.5%(105/110)。本组中Ⅰ型肾嫌色细胞癌107例,Ⅱ型肾嫌色细胞癌6例。肾嫌色细胞癌单因素Kaplan-Meier预后分析显示,Ⅱ型肾嫌色细胞癌的预后有好于Ⅰ型的趋势,但差异无统计学意义(P=0.515);不同症状、不同T分期和美国癌症联合委员会(AJCC)分期的肾嫌色细胞癌患者预后的差异均有统计学意义(P值均0.05)。结论肾嫌色细胞癌是预后较好的肾癌亚型之一,其中Ⅱ型预后相对更好。患者的症状、肿瘤的大小和AJCC分期可以作为判断肾嫌色细胞癌预后的重要因素。
[Abstract]:Objective to analyze the clinical characteristics of single center of chromophobe cell renal carcinoma and to investigate the clinical indicators related with prognosis of chromophobe renal cell carcinoma. Methods a retrospective analysis from January 2005 to May 2015 in Changhai Hospital of Shanghai during surgery, and the postoperative pathological examination confirmed renal chromophobe cell carcinoma 113 cases of patients with clinical, pathological and follow-up data. The end point was the total survival time, the survival analysis data were calculated by Kaplan-Meier method, and the survival rate was compared with the Log-rank method. 4.8% of all renal cell carcinoma results of chromophobe renal cell carcinoma (113/2 355) for the same period, the median age was 50.96 years old, male and female ratio of 1.01 1,80 cases (70.8%) without symptoms. Chromophobe renal cell carcinoma, 1, 3, 5 year survival rates were 98.2% (108/110), 96.4% (106/110), 95.5% (105/110). 107 cases of type I in this group of chromophobe renal cell carcinoma, 6 cases of type II renal chromophobe cell carcinoma. Chromophobe renal cell carcinoma Kaplan-Meier univariate prognostic analysis showed that there is good to the type of prognosis of type II chromophobe renal cell carcinoma, but the difference was not statistically significant (P=0.515); different symptoms and T staging and the American Joint Committee on cancer (AJCC) chromophobe renal cell carcinoma prognosis staging were statistically significant (the P value was 0.05). Conclusion chromophobe renal cell carcinoma is one of the better prognosis of renal cell carcinoma subtype, type II, the prognosis is relatively better. The patient's symptoms, tumor size and AJCC stage can be used as an important factor to determine the prognosis of chromophobe renal cell carcinoma.
【作者单位】：上海长征医院泌尿外科;上海长海医院病理科;上海长海医院泌尿外科;
【基金】：国家自然科学基金面上项目(81272817,81172447) 上海市自然科学基金(11ZR1447800)资助项目
【分类号】：R737.11
【正文快照】： 不同亚型的肾癌具有独特的形态学、遗传学特征,且预后相关因素也有所差异。肾嫌色细胞癌由Thoenes等[1]于1985年首次报道,是肾细胞癌中的一种少见亚型。国外研究结果表明,肾嫌色细胞癌占肾细胞癌的4.0%~5.9%。国内尚缺乏肾嫌色细胞癌的大宗报道,但随着病理学技术和精确医学的

【相似文献】