达泊西汀治疗早泄的疗效和安全性分析

发布时间：2017-12-30 22:06

本文关键词：达泊西汀治疗早泄的疗效和安全性分析　出处：《中华男科学杂志》2016年05期 　论文类型：期刊论文

【摘要】：目的:探讨达泊西汀用于治疗早泄(PE)的临床疗效。方法:PE患者116例,随机分为观察组(60例)和对照组(56例),观察组年龄23~49(33.1±1.4)岁,病程0.5~5(1.83±0.22)年,对照组年龄24~46(35.0±1.5)岁,病程1~7(1.97±0.25)年,2组年龄和病程差异无显著性(P0.05)。观察组按需口服达泊西汀,30 mg/次;对照组予以氟西汀口服,20 mg/次,1次/d。对比2组的临床总体印象变化(CGIC)、早泄评估量表(PEP)、平均阴道内射精潜伏期(IELT)及不良反应。结果:治疗前后IELT观察组[(0.86±0.17)min vs(4.32±2.23)min]和对照组[(0.88±0.15)min vs(4.17±2.26)min],较治疗前均显著延长(P0.05),组间无显著性差异(P0.05);观察组与对照组治疗后的CGIC总有效率分别为85.00%、82.14%,组间比较无显著性差异(P0.05);治疗后2组PEP量表中控制射精能力(PCOE)、早泄相关苦恼得分(ERPD)、性交满意度(SSI)及早泄相关良性沟通困难得分(ERID)均显著提高(P0.05),组间比较无显著性差异(P0.05);观察组的不良反应明显低于对照组(3.33%vs 30.36%,P0.05)。结论:达泊西汀治疗PE疗效显著,能够延长阴道内射精潜伏期,提高性生活质量,且不良反应较少。
[Abstract]:Objective: to investigate the clinical efficacy of dapoxetine in the treatment of premature ejaculation. Methods: 116 cases of PE were randomly divided into observation group (n = 60) and control group (n = 56). The age of the observation group was 2349, 33.1 卤1.4 years old, the course of disease was 0.50.83 卤0.22 years, and the control group was 2446 卤35.0 卤1.5 years old. There was no significant difference in age and course of disease between the two groups in the course of disease (1: 7 卤1. 97 卤0. 25). In the observation group, 30 mg / time of dapoxetine was given to the patients in the observation group, and there was no significant difference in age and course of disease between the two groups. The control group was given fluoxetine orally 20 mg / once a day. The changes of general clinical impression (CGICI) and PEP (early ejaculation evaluation scale) were compared between the two groups. Mean intravaginal ejaculation latency (IELTT) and adverse reactions. Results: IELT observation group before and after treatment. [0. 86 卤0. 17 vs(4.32 卤2. 23 min and control group. [Vs(4.17 卤2.26 vs(4.17 was 0.88 卤0.15??? The total effective rate of CGIC in the observation group and the control group was 85.00 and 82.14, respectively. There was no significant difference between the two groups (P 0.05). After treatment, the control ejaculation ability and the scores of premature ejaculation related distress were measured by PEP scale in two groups. Sexual intercourse satisfaction (SSI) and the score of benign communication difficulties associated with premature ejaculation were significantly increased (P 0.05), but there was no significant difference between the two groups (P 0.05). The adverse reactions in the observation group were significantly lower than those in the control group (3.33 vs 30.36 P0.050.Conclusion: Dapoxetine is effective in the treatment of PE and can prolong the latent period of intravaginal ejaculation. Improve the quality of sexual life, and less adverse reactions.
【作者单位】：河南中医学院第一附属医院泌尿外科;
【分类号】：R698.1
【正文快照】： Correspondence to:WANG Suo-gang,email:wangsuogang2005@126.comReceived:January 7,2016;accepted:March 2,2016早泄(PE)是临床常见男性性功能障碍之一,主要是指插入阴道前或插入后1 min左右射精,人群发病率约为14%~33%[1]。患者由于完全或几乎不能自主控制射精,极易产生挫

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