肾移植受者侵袭性曲霉菌感染的早期血清学诊断

发布时间：2017-12-31 06:14

本文关键词：肾移植受者侵袭性曲霉菌感染的早期血清学诊断　出处：《南方医科大学学报》2015年11期 　论文类型：期刊论文

【摘要】：目的探讨1,3-β-D葡聚糖(BG)与半乳甘露聚糖(GM)在肾移植受者侵袭性曲霉菌感染(IA)早期血清学诊断中的临床价值。方法收集69例肾移植受者的血液标本,分成:确诊组、临床诊断组、拟诊组和非感染组,对4组血液样本进行检测及统计学分析。结果确诊组、临床诊断组、拟诊组的BG浓度显著高于对照组(P0.05),其敏感性、特异性阳性预测值、阴性预测值分别为69.49%、70%、93.18%、35.71%。3组的GM浓度亦显著高于对照组(P0.05);其敏感性、特异性阳性预测值、阴性预测值分别为84.75%、90%、96.15%、52.63%。结论血中的BG和GM浓度检测可以作为肾移植受者IA的早期诊断依据之一,浓度升高提示发生感染的可能。同时行BG实验与GM检测能提高诊断效能,减少漏诊。
[Abstract]:Objective to explore 1. 3- 尾 -D glucan (BGG) and galactomannan (GM) in invasive aspergillus infection in renal transplant recipients (IAA). Clinical value of early serological diagnosis. Methods Blood samples from 69 renal transplant recipients were collected. The patients were divided into four groups: the confirmed group, the clinical diagnosis group, the intended group and the non-infection group. The blood samples of 4 groups were detected and statistically analyzed. The BG concentration in the proposed group was significantly higher than that in the control group (P 0.05). The sensitivity, specificity and negative predictive value of BG were 69.49% and 7093.18%, respectively. The concentration of GM in the group 35.71.3 was also significantly higher than that in the control group (P 0.05). The sensitivity, specific positive predictive value and negative predictive value were 96.15%. Conclusion the detection of BG and GM in blood can be used as an early diagnostic basis for IA in renal transplant recipients. The higher concentration of BG and GM can improve the diagnostic efficiency and reduce the missed diagnosis.
【作者单位】：南方医科大学珠江医院器官移植中心;
【基金】：广东省医学科学技术研究基金(WSTJJ20101201362101197808290619)
【分类号】：R699.2;R519
【正文快照】： 随着实体器官移植及造血干细胞移植等技术的广泛开展、免疫抑制剂的大量应用、导管介入及导管留置技术的广泛开展及人类免疫缺陷病毒(HIV)在全球的持续蔓延,侵袭性真菌感染(IFI)的发病率及死亡率在全球范围内显著上升[1-4]。IFI已成为器官移植受者移植物丢失及受者死亡的主要

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