膀胱黏膜毒蕈碱型胆碱能受体密度与前列腺术后膀胱痉挛的相关性研究

发布时间：2017-12-31 23:20

本文关键词：膀胱黏膜毒蕈碱型胆碱能受体密度与前列腺术后膀胱痉挛的相关性研究　出处：《中国现代医学杂志》2016年15期 　论文类型：期刊论文

【摘要】：目的探讨膀胱黏膜毒蕈碱型胆碱能受体(M受体)M2、M3亚型的密度与前列腺电切术后膀胱痉挛的相关性。方法选取2012年5月-2015年5月医院收治的良性前列腺增生(BPH)患者作为研究对象,将其分为合并膀胱过度活动症(OAB)观察组和不合并OAB对照组,再将观察组分为发生膀胱痉挛组及不发生膀胱痉挛组,比较各组M2、M3受体的密度及其相关性。结果观察组术后膀胱痉挛的发生率高于对照组;观察组M2、M3受体密度均低于对照组;观察组中发生膀胱痉挛患者的M3受体密度低于不发生膀胱痉挛患者的M3受体密度。结论膀胱黏膜M3受体密度与前列腺术后发生膀胱痉挛存在相关性,提示M3受体可能参与膀胱痉挛的发病机制。
[Abstract]:Objective to study muscarinic cholinergic receptor M receptor M 2 in bladder mucosa. The correlation between the density of M3 subtype and bladder spasm after prostatectomy methods the patients with benign prostatic hyperplasia (BPH) treated in our hospital from May 2012 to May 2015 were selected as the study objects. It was divided into the observation group with bladder hyperactivity syndrome and the control group without OAB. Then the observation group was divided into the bladder spasm group and the no bladder spasm group. The M2 in each group was compared. Results the incidence of bladder spasm in the observation group was higher than that in the control group. The density of M2M3 receptor in the observation group was lower than that in the control group. The density of M3 receptor in patients with bladder spasm was lower than that in patients without bladder spasm. Conclusion there is a correlation between the density of M3 receptors in bladder mucosa and bladder spasm after prostatic surgery. These results suggest that M 3 receptor may be involved in the pathogenesis of bladder spasm.
【作者单位】：广东省潮州市人民医院泌尿外科;
【分类号】：R699.8
【正文快照】： 琼脂糖凝胶电泳显示28 S、18 S和5 S 3条带清晰可见,无明显降解附图RNA鉴定28 S18 S5 S性疾病。经尿道前列腺电切术(transurethral resec-tion of the prostate,TURP)是治疗BPH的金标准[1]。然而TURP术后患者容易发生膀胱痉挛,膀胱痉挛会加重术后出血及患者痛苦,如何预防及控

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