上段输尿管结石经输尿管镜与经体外震波碎石术后对肾脏的损伤

发布时间：2018-01-01 18:23

本文关键词：上段输尿管结石经输尿管镜与经体外震波碎石术后对肾脏的损伤　出处：《宁夏医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的对比上段输尿管结石患者经输尿管镜下钬激光碎石术与体外震波碎石术术前、术后尿液中NGAL与α1微球蛋白含量的变化,比较两种治疗方法对肾功能的损害程度。方法筛选我院2014年1月至2014年6月60例单侧上段输尿管结石患者,随机编入输尿管镜钬激光碎石组与体外震波碎石组。留取患者术前2h,术后12h、24h尿液标本,检测不同时间点患者尿液中NGAL与α1微球蛋白含量。结果两组患者术前2h尿液中NGAL、α1-MG差异无统计学意义(P0.05),术后12h、24h尿液NGAL浓度均高于术前2h(P0.05)。ESWL组术后12h、24h尿液NGAL浓度高于URL组(P0.05)。两组患者术后12h、24h尿液α1-MG浓度均高于术前2h(P0.05)。EWSL组术后12h、24h尿液α1-MG浓度高于URL组(P0.05)。结论输尿管镜下钬激光碎石术与体外震波碎石术治疗上段输尿管结石均会造成一定程度的肾脏损伤,体外震波碎石术对肾脏的损伤大于输尿管镜下钬激光碎石术。
[Abstract]:Objective to compare the changes of NGAL and 伪 1 microglobulin in urine of patients with upper ureteral calculi before and after transurethral lithotripsy with holmium laser lithotripsy and extracorporeal shock wave lithotripsy. Methods 60 patients with unilateral upper ureteral calculi were selected from January 2014 to June 2014. Urine samples were randomly divided into ureteroscopic holmium laser lithotripsy group and extracorporeal shock wave lithotripsy group. The levels of NGAL and 伪 1 microglobulin in urine were measured at different time points. Results there was no significant difference in urine NGAL and 伪 1-MG between the two groups 2 hours before operation (P 0.05). Urine NGAL concentration at 12 h after operation was higher than that at 2 h postoperatively (P 0.05). Urine NGAL concentration in 24 h was higher than that in URL group (P 0.05). The concentration of urine 伪 1-MG in 24 hours was higher than that in 2 h before operation (P 0.05) and 12 h after operation in EWSL group. The concentration of urine 伪 1-MG in 24 hours was higher than that in URL group (P 0.05). Conclusion Holmium laser lithotripsy under ureteroscope and extracorporeal shock wave lithotripsy for upper ureteral calculi can cause renal injury to some extent. Extracorporeal shock wave lithotripsy caused more damage to kidney than ureteroscopic holmium laser lithotripsy.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R699

【共引文献】