阿呋唑嗪和坦索罗辛对输尿管结石的临床疗效研究

发布时间：2018-01-02 12:03

本文关键词：阿呋唑嗪和坦索罗辛对输尿管结石的临床疗效研究　出处：《中国临床药理学杂志》2016年03期 　论文类型：期刊论文

【摘要】：目的观察α受体阻滞药阿呋唑嗪和坦索罗辛对输尿管结石的临床疗效和安全性。方法 320例确诊为输尿管结石的患者随机分为试验组和对照组,各160例。试验组口服盐酸阿呋唑嗪缓释片,每次10 mg,每天1次,对照组口服盐酸坦索罗辛缓释胶囊,每次0.4 mg,每天1次,2组疗程均为4周。所有患者在治疗期间保持每日饮水2000~3000 m L。记录每例患者的结石位置、大小等,每位患者临床检查结石排出,或者经过临床医师会诊需要改为手术治疗的为记录和研究结束点。结果试验组结石排出率为63.13%,结石排出时间为(9.43±1.34)d;对照组结石排出率为76.25%,结石排出时间为(8.48±1.66)d,差异有统计意义(P0.05)。试验组输尿管上、中、下段结石排出率分别为53.85%,60.87%,65.77%,对照组分别为52.38%,62.92%,83.93%;试验组上、中、下段结石排出时间(9.50±1.22),(9.14±1.35),(9.48±1.37)d,对照组分别为(9.45±1.44),(8.76±1.03),(8.32±1.74)d,试验组和对照组输尿管上段和中段结石的排出率与排石时间差异无统计学意义(P0.05),下段结石排出率和排出时间差异有统计学意义(P0.05)。结论坦索罗辛和阿呋唑嗪对输尿管上段和中段的结石排出率及排出时间无明显差异,对输尿管下段结石,坦索罗辛优于阿呋唑嗪。
[Abstract]:Objective to observe the clinical efficacy and safety of 伪 -receptor blockers alfuzosin and tamsoloxine in the treatment of ureteral calculi. Methods 320 patients with ureteral calculi were randomly divided into two groups: the experimental group and the control group. Each 160 cases were treated with alfuzosin hydrochloride sustained-release tablets once a day, and the control group with 0.4 mg of tansuloxine hydrochloride sustained-release capsules once a day. The course of treatment in both groups was 4 weeks. During the treatment period, all the patients maintained drinking water of 2000m / L daily. The location and size of the stones were recorded in each patient, and the stones were excreted from each patient by clinical examination. Results in the test group, the stone excretion rate was 63.13 and the time of stone excretion was 9.43 卤1.34 days. In the control group, the stone excretion rate was 76.25, and the stone excretion time was 8.48 卤1.66 days. The difference was statistically significant (P 0.05). The excretion rate of stones in the lower segment was 53.85 and 60.87, respectively, and that in the control group was 52.38 and 62.92respectively, and 83.93 in the control group. In the test group, the time of excretion of stones in the middle and lower segments was 9.50 卤1.22, 9.14 卤1.35 and 9.48 卤1.37 days, respectively, and that in the control group was 9.45 卤1.44). The excretion rate of upper and middle ureteral calculi in the test group and the control group was not significantly different from that in the control group (P 0.05). Conclusion there is no significant difference between tamsoloxine and alfuzosin in the upper and middle ureteral calculi excretion rate and time. For lower ureteral calculi, tamsoloxine is superior to alfuzosin.
【作者单位】：新疆医科大学第一附属医院药学部;新疆医科大学第一附属医院泌尿中心;
【基金】：新疆医科大学第一附属医院药学专项基金资助项目(No.2012YX05)
【分类号】：R693.4
【正文快照】： 向云霞1a,刘冰1a,安恒庆1b,彭红玉1a(1.新疆医科大学第一附属医院,a.药学部;b.泌尿中心,乌鲁木齐830011)XIANG Yun-xia1a,LIU Bing1a,AN Heng-qing1b,PENG Hong-yu1a(1.a.Department of Pharmacy;b.Urology Center,The First TeachingHospital of Xinjiang MedicalUniversity,

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