硫辛酸对老年2型糖尿病勃起功能障碍患者的疗效及对其氧化应激的影响

发布时间：2018-01-03 18:44

本文关键词：硫辛酸对老年2型糖尿病勃起功能障碍患者的疗效及对其氧化应激的影响　出处：《中国老年学杂志》2015年18期 　论文类型：期刊论文

【摘要】：目的观察硫辛酸对老年2型糖尿病(T2DM)勃起功能障碍(ED)患者的疗效及对其氧化应激的影响。方法选取老年男性T2DM合并ED患者60例(B组),老年男性T2DM无ED患者60例(A组)。两组患者均进行国际勃起功能指数问卷-5评分,比较两组患者的氧化应激水平:超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH)、SOD/MDA比值。B组应用硫辛酸干预治疗3 w,观察干预前后氧化应激水平的变化及临床疗效。结果干预前B组患者的氧化应激水平较A组升高(均P0.05)。硫辛酸干预后,B组的氧化应激水平较治疗前降低国际勃起功能指数问卷-5评分升高(均P0.05)。结论硫辛酸可降低老年男性T2DM并ED患者的氧化应激水平,疗效肯定。
[Abstract]:Objective To observe the effect of lipoic acid on elderly patients with type 2 diabetes mellitus (T2DM) with erectile dysfunction (ED) patients and its effects on oxidative stress. Methods 60 cases of elderly male patients with T2DM combined with ED (B group), elderly male T2DM patients without ED 60 cases (A group). Two groups of patients were treated with erectile dysfunction index questionnaire -5 score were compared between the two groups: oxidative stress levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH), the ratio of SOD/MDA in group.B, 3 W lipoic acid treatment, clinical curative effect and the changes of oxidative stress levels were observed before and after the intervention. The intervention of oxidative stress the level of B group were significantly higher than those in group A (all P0.05). Lipoic acid intervention, the level of oxidative stress in B group decreased the international index of erectile function questionnaire -5 score increased (P0.05). Conclusion lipoic acid can reduce the oxidative stress in elderly male patients with ED and T2DM The level, the curative effect is positive.

【作者单位】：徐州市第一人民医院内分泌科;
【基金】：徐州市卫生局医学科研项目(No.XWJ2011009)
【分类号】：R587.2;R698
【正文快照】： 勃起功能障碍(ED)是男性糖尿病患者常见的慢性并发症。糖尿病患者ED发病率是一般人群的3倍,且糖尿病患者ED症状比普通ED患者更为严重〔1〕。糖尿病患者ED可发生于任何年龄,50岁以上的患者发生率可高达50%~70%〔2,3〕。本研究旨在探讨老年男性2型糖尿病(T2DM)性患者氧化应激水

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