腹膜透析患者固有腹膜高转运的相关因素分析

发布时间：2018-01-03 23:22

本文关键词：腹膜透析患者固有腹膜高转运的相关因素分析　出处：《东南大学学报(医学版)》2016年01期 　论文类型：期刊论文

【摘要】：目的:探讨国人固有型腹膜高转运患者的临床特点及其相关因素。方法:回顾性总结2011年1月至2014年6月因终末期肾脏病行腹膜透析置管的194例患者的临床资料,将患者按照透析开始后的腹膜转运特性分为低转运组(21例)、低平均转运组(55例)、高平均转运组(93例)和高转运组(25例)4组,比较患者人口学资料、透析前的生化指标以及白介素6(interleukin-6,IL-6)基因单核苷酸多态性;Logistic回归分析患者腹膜高转运的独立危险因素。结果:4组患者性别分布、心血管并发症以及钙磷乘积水平存在显著差异(P0.05);4组患者中,IL-6基因T15A多态性分布有显著差异(P0.05)。回归分析显示,钙磷乘积、心血管并发症以及IL-6基因T15A多态性是本组患者腹膜高转运的独立危险因素。结论:腹膜透析患者透析前钙磷乘积水平、心血管并发症以及IL-6基因T15A多态性可能与国人腹膜高转运有关。
[Abstract]:Objective: To investigate the clinical characteristics of the inherent high peritoneal transport type patients and its related factors. Methods: a retrospective analysis from January 2011 to June 2014 due to end-stage kidney disease clinical data for 194 patients with peritoneal dialysis tube patients, patients according to peritoneal transport characteristics after initiation of dialysis is divided into low transport group (21 cases). Low average transport group (55 cases), high average transport group (93 cases) and high transport group (25 cases) in 4 groups, compared with demographic data, biochemical indexes before dialysis and interleukin 6 (interleukin-6, IL-6) gene polymorphisms; Logistic regression analysis of independent risk factors in patients with high peritoneal transport. Results: 4 groups of patients with gender distribution, there are significant differences in cardiovascular complications and the level of calcium phosphate product (P0.05); the 4 groups of patients, there is significant difference between IL-6 gene T15A polymorphism (P0.05). The regression analysis showed that the calcium phosphorus product, cardiovascular The T15A polymorphism of IL-6 gene is an independent risk factor for the high transport of peritoneum in this group. Conclusion: the level of calcium and phosphorus, the cardiovascular complications and the T15A polymorphism of IL-6 gene in peritoneal dialysis patients may be related to the high transport of peritoneum in Chinese patients.

【作者单位】：南京大学医学院附属鼓楼医院肾内科;
【分类号】：R692.5
【正文快照】： (Department of Nephrology,Drum Tower Hospital Affiliated to Medical College ofNanjing University,Nanjing 210008,China)腹膜透析(peritoneal dialysis,PD)是终末期肾脏病替代治疗的一种重要方法。近年来的研究表明PD患者的腹膜转运特性与患者的预后密切相关。腹膜高转

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