胱抑素C联合eGFR-MDRD诊断早期DN的研究

发布时间：2018-01-06 02:24

本文关键词：胱抑素C联合eGFR-MDRD诊断早期DN的研究　出处：《中国免疫学杂志》2015年10期 　论文类型：期刊论文

【摘要】：目的:比较分析胱抑素C(Cys C)、BUN、Scr、e GFR-MDRD和e GFR-cys等检测指标在诊断早期DN中的应用价值。方法:随机收集2012年1月至2014年10月本院收治的2型糖尿病(Type 2 diabetes mellitus,T2DM)患者214例和来本院体检的100名健康人,并根据尿蛋白排泄率分为单纯的T2DM组和糖尿病组(DN组),收集患者的血肌酐(Scr)、尿素氮(BUN)、血清胱抑素C(Cys C)等检测指标,并采用简化的MDRD公式根据Scr估算出e GFR(e GFR-MDRD),而Cys C则使用CHINAcys方程计算得出e GFR(e GFR-cys),对这些检测指标做统计学分析。结果:DN组和对照组相比BUN、Scr、Cys C、e GFRMDRD和e GFR-cys都有显著性变化,其中BUN、Scr和Cys C均显著高于对照组;e GFR-MDRD和e GFR-cys与对照组相比显著较低,5个检测指标均P0.05;五个常用的检测指标ROS曲线面积都大于0.5,且P0.05;单个检测指标中Cys C的检测指标最高能够达到80.38,其次是BUN和e GFR-MDRD;而联合检测中e GFR-MDRD+Cys C的灵敏度和约登指数远远高于e GFRMDRD+e GFR-cys和其他单项检测指标。结论:e GFR-MDRD结合Cys C指标的诊断对早期DN筛查是一种有效、可行且准确度较高的方法。
[Abstract]:Objective: To compare the serum cystatin C (Cys C), BUN, Scr, GFR-MDRD and E value of E GFR-cys detection index in early diagnosis of DN. Methods: type 2 diabetes mellitus were randomly collected from January 2012 to October 2014 in our hospital (Type 2 diabetes mellitus, T2DM) in 214 patients and to the hospital 100 healthy people, and according to the urinary protein excretion rate divided into T2DM group and simple diabetes group (group DN), serum creatinine (Scr) were collected, blood urea nitrogen (BUN), serum cystatin C (Cys C) and other indexes, and the simplified MDRD formula according to the estimated e (e GFR Scr GFR-MDRD, Cys and C) using the CHINAcys equation E GFR (E GFR-cys), do statistical analysis on these indexes. Results: DN group and control group compared to BUN, Scr, Cys C, e GFRMDRD and E GFR-cys have significant changes, including BUN, Scr and Cys C were significantly higher than that of control group GFR-MDRD and E GFR-cys and E; The control group was significantly lower than that of 5 indexes were P0.05; five commonly used indexes of ROS curve area is greater than 0.5, and the P0.05 Cys C single index detection; detection index in the highest reaches 80.38, followed by BUN and E GFR-MDRD; and the combined detection sensitivity and Youden index in E GFR-MDRD+Cys C far e GFRMDRD+e is higher than that of GFR-cys and other indicators. Conclusion: e GFR-MDRD combined with the Cys C index for early diagnosis of DN screening is an effective, feasible and accurate.

【作者单位】：海南省人民医院检验科;
【分类号】：R587.2;R692.9
【正文快照】： 糖尿病肾病(Diabetic nephropathy,DN)是糖尿病全身性微血管并发症之一,也是临床上慢性肾功能不全的主要病因。它的早期特征表现在尿蛋白微量排泄增加,所以糖尿病肾病目前主要以尿蛋白排泄率(Urinary albumin excretion,UAE)作为早期临床DN的诊断标准[1]。但是尿路感染等多种

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