DNA免疫吸附联合糖皮质激素、环磷酰胺对老年系统性红斑狼疮肾炎患者免疫功能及肾功能的影响

发布时间：2018-01-13 07:02

本文关键词：DNA免疫吸附联合糖皮质激素、环磷酰胺对老年系统性红斑狼疮肾炎患者免疫功能及肾功能的影响　出处：《中国老年学杂志》2015年23期 　论文类型：期刊论文

【摘要】：目的研究DNA免疫吸附联合糖皮质激素、环磷酰胺对老年系统性红斑狼疮(SLE)肾炎患者免疫功能及肾功能的影响。方法 34例SLE肾炎患者采用随机数字表法分为观察组和对照组各17例,观察组接受DNA免疫吸附联合糖皮质激素、环磷酰胺治疗,对照组接受糖皮质激素、环磷酰胺治疗,比较两组免疫功能指标、肾功能指标及治疗效果。结果观察组肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白水平均明显低于对照组(P0.05)。观察组血清中IgA、IgG、IgM含量明显低于对照组(P0.05),补体C3和C4含量明显高于对照组(P0.05)。观察组治疗有效率明显高于对照组(P0.05)。结论 DNA免疫吸附联合糖皮质激素、环磷酰胺有助于改善SLE肾炎患者肾功能,调节免疫功能,提高治疗效果。
[Abstract]:Objective to study the combination of DNA immunosorbent assay and glucocorticoid. Effects of cyclophosphamide on immune function and renal function in elderly patients with systemic lupus erythematosus (SLE) nephritis methods 34 patients with SLE nephritis were randomly divided into observation group (n = 17) and control group (n = 17). The observation group was treated with DNA immunosorbent combined with glucocorticoid and cyclophosphamide while the control group was treated with glucocorticoid and cyclophosphamide. Results the 24 h urinary protein levels of creatinine and bun in the observation group were significantly lower than those in the control group (P 0.05). The serum levels of IgA in the observation group were significantly lower than those in the control group. The content of IgGN IgM was significantly lower than that of control group (P0.05). The levels of complement C3 and C4 were significantly higher than those of the control group (P 0.05). The effective rate of treatment in the observation group was significantly higher than that in the control group. Conclusion DNA immunosorbent assay combined with glucocorticoid. Cyclophosphamide can improve renal function, regulate immune function and improve therapeutic effect in patients with SLE nephritis.
【作者单位】：福建医科大学附属第一医院风湿血液科;广西医科大学附属第一医院肾脏内科;中国免疫吸附研究委员会;
【基金】：福建省自然科学基金计划项目(2015J01459)
【分类号】：R593.242
【正文快照】： 系统性红斑狼疮(SLE)是临床常见的自身免疫性疾病,自身抗体的产生及抗原抗体复合物的形成会在靶器官局部沉积并造成功能损害。肾脏是该病最常累及的靶器官,亦称之为狼疮性肾炎。激素联合细胞毒药物是临床最基本的治疗思路,但是不良反应较多、疗效并不理想。免疫吸附(IA)治疗是

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