老年患者尿路感染肠球菌属的耐药性分析

发布时间：2018-01-14 17:18

本文关键词：老年患者尿路感染肠球菌属的耐药性分析　出处：《中华医院感染学杂志》2015年12期 　论文类型：期刊论文

【摘要】：目的探讨老年尿路感染患者中段尿粪肠球菌及屎肠球菌的耐药性,为指导临床用药以及分析肠球菌属耐药性提供依据。方法回顾性分析2011年7月-2013年7月老年患者送检的中段尿标本,共分离出粪肠球菌71株、屎肠球菌96株,药敏试验使用K-B纸片扩散法,采用WHONET 5.1软件对研究数据进行分析处理,分析肠球菌属的耐药性。结果肠球菌属检出率泌尿外科占33.53%、重症医学科占23.35%、内分泌科占15.57%;粪肠球菌对红霉素、四环素以及环丙沙星的耐药率最高,分别为87.32%、73.24%、69.01%,对万古霉素的耐药率最低为2.82%,屎肠球菌对环丙沙星、利福平以及高浓度庆大霉素的耐药率最高,分别为95.83%、94.79%、92.71%,对万古霉素的耐药率最低为5.21%。结论由于粪肠球菌以及屎肠球菌所导致的老年患者尿路感染,治疗可首选万古霉素,但是仍然需要重视对菌株的培养以及耐药性分析,减少抗菌药物的盲目运用,以有效降低耐药菌株的产生,同时提高治疗效果。
[Abstract]:Objective to investigate the drug resistance of Enterococcus faecalis and Enterococcus faecium in middle urinary tract infection in elderly patients. Methods from July 2011 to July 2013, 71 strains of Enterococcus faecalis were isolated. 96 strains of Enterococcus faecium were tested by K-B disk diffusion method and WHONET 5.1 software was used to analyze and process the data. Results the detection rate of Enterococcus was 33.53 in urology department, 23.35 in critical medicine department and 15.57 in endocrine department. The resistance rates of Enterococcus faecalis to erythromycin, tetracycline and ciprofloxacin were 87.32, 73.24 and 2.82%, respectively. The resistance rate of Enterococcus faecium to ciprofloxacin, rifampicin and high concentration of gentamicin was 95.83%, 94.79% and 92.71%, respectively. The lowest rate of vancomycin resistance was 5.21. Conclusion the urinary tract infection caused by Enterococcus faecalis and Enterococcus faecium is the first choice in the treatment of urinary tract infection. But we still need to pay attention to the cultivation of strains and drug resistance analysis, reduce the blind use of antimicrobial agents, in order to effectively reduce the production of drug-resistant strains, and improve the therapeutic effect.
【作者单位】：宁波市第二医院肾内二科;
【基金】：浙江省卫生厅基金资助项目(ZW-2010A029)
【分类号】：R691.3
【正文快照】： 肠球菌属细菌作为一种条件致病菌已成为医院感染,特别是尿路感染中的重要病原菌。临床中常见肠球菌属细菌为粪肠球菌及屎肠球菌,近年来,随着抗菌药物在临床中的大量运用,肠球菌属其耐药性也变得日益严重,因此给尿路感染患者的治疗带来了很大困难[1]。本研究探讨医院老年尿路感

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