终末期肾脏病对非瓣膜性心房颤动患者发生卒中及出血事件的影响

发布时间：2018-01-19 23:03

  本文关键词： 综述 心房颤动 肾疾病 血栓形成 出血　出处：《中国循环杂志》2016年02期 　论文类型：期刊论文

【摘要】：非瓣膜性心房颤动(房颤)是最常见的心律失常,卒中是房颤严重并发症之一。终末期肾脏病(ESRD)与房颤有共同的危险因素。有研究报道,ESRD可通过改变多种生理机制增加房颤患者的卒中及出血风险,并与远期预后相关。抗凝治疗作为房颤患者卒中的一级及二级预防可使患者获益,但如何准确细致地评估房颤伴ESRD患者抗凝治疗的获益和风险仍不明确,多项评价房颤伴ESRD患者抗凝治疗的临床实验结果不尽相同。本文就ESRD对非瓣膜性房颤患者发生卒中与出血事件的影响进行综述。
[Abstract]:Non-valvular atrial fibrillation (AF) is the most common arrhythmia, stroke is one of the serious complications of AF. ESRD has a common risk factor with AF. ESRD can increase the risk of stroke and hemorrhage in patients with atrial fibrillation by changing many physiological mechanisms and is related to long-term prognosis. Anticoagulant therapy can benefit patients as the primary and secondary prevention of stroke in patients with atrial fibrillation. However, how to accurately and meticulously assess the benefits and risks of anticoagulant therapy in patients with atrial fibrillation with ESRD remains unclear. The clinical trial results of anticoagulant therapy in patients with atrial fibrillation associated with ESRD are different. This article reviews the effects of ESRD on stroke and bleeding events in patients with non-valvular atrial fibrillation.
【作者单位】： 南昌大学第二附属医院心内科;
【分类号】：R541.75;R692.5
【正文快照】： 心房颤动(房颤)是临床上常见的心律失常,可显著增临床研究发现,房颤伴ESRD患者卒中/全身血栓事加患者的卒中风险。有报道称,20%的卒中与房颤患者左心件发生率高于肾功能正常的房颤患者[风险比(HR):1.83,房血栓形成有关[1]。近年来,终末期肾脏病(ESRD)对房颤95%可信区间(CI):1.，

本文编号：1445854