实验兔单侧输尿管部分梗阻后基础状态下肾小球滤过功能的变化特点

发布时间：2018-01-25 08:47

本文关键词： 输尿管梗阻肾小球滤过率放射性核素显像兔　出处：《实用医学杂志》2016年14期 　论文类型：期刊论文

【摘要】：目的:观察兔输尿管部分梗阻后基础肾功能的变化特点。方法:30只成年健康日本大耳白兔分为对照组6只和梗阻组24只。采用套管法制作右输尿管部分梗阻模型,据梗阻时间均分为4组,即梗阻7、14、28和56 d组。以肾动态显像测量各组肾小球滤过率(GFR),分析其肾功能与梗阻时间的关系,并观察健侧肾脏功能的变化。结果:(1)对照组双肾GFR比较差异无统计学意义(t=-0.145,P=0.894);梗阻组右肾GFR均低于左肾(P0.05)。(2)右肾GFR比较,梗阻7 d组与对照组差异具有统计学意义(t=5.066,P=0.001),梗阻7、14、28、56 d组间差异无统计学意义(P0.05)。(3)左肾GFR比较,对照组、梗阻7、14、28、56 d组间差异无统计学意义(P0.05)。结论 :单侧输尿管部分梗阻后,梗阻肾脏的功能呈现先期大幅度下降之后趋于稳定的变化特征,健侧肾脏的基础肾功能未见代偿。
[Abstract]:Objective: to observe the changes of basic renal function after partial ureteral obstruction in rabbits. Thirty healthy Japanese rabbits were divided into control group (n = 6) and obstruction group (n = 24). According to the time of obstruction, the patients were divided into 4 groups, namely 7145d and 56d. The glomerular filtration rate (GFRV) was measured by dynamic renal imaging, and the relationship between the renal function and the time of obstruction was analyzed. The changes of renal function in healthy side were observed. Results there was no significant difference in GFR between the two kidneys in the control group. The GFR of the right kidney in the obstruction group was lower than that in the left kidney (P 0.05). The GFR of the right kidney was significantly higher in the obstruction group than that in the control group on the 7th day (P < 0.05). The difference between the obstruction group and the control group was statistically significant (P < 0.05). There was no significant difference in GFR of left kidney between the two groups (P < 0.05). In the control group, there was no significant difference between the two groups (P < 0.05). In the control group, there was no significant difference between the two groups (P < 0.05). Conclusion: after unilateral partial ureteral obstruction, the function of the obstructed kidney decreased significantly and then tended to change steadily. The basic renal function of the healthy kidney was not compensated.
【作者单位】：武汉大学中南医院核医学科;武汉大学中南医院急救中心外科;武汉大学医学部临床医学系;
【基金】：湖北省自然科学基金资助项目(编号:2011CHB035)
【分类号】：R699.4
【正文快照】： 汪长银杨奇盛高纯买买提李顺江凌龙涂小朋临床上常见的输尿管梗阻多为部分梗阻。输尿管部分梗阻后肾功能的变化规律,国内外报道不多。肾动态显像是测量分肾功能最为准确的方法,在评价梗阻肾脏的功能变化方面具有重要意义[1-2]。以家兔为实验对象,国内研究者测量的实验兔的肾小

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