前列腺癌组织中ERG蛋白的表达变化及意义

发布时间：2018-01-27 02:20

  本文关键词： 前列腺肿瘤 ERG蛋白 前列腺增生 Gleason评分　出处：《山东医药》2016年01期 　论文类型：期刊论文

【摘要】：目的观察前列腺癌(PCa)组织中ERG蛋白的表达变化并探讨意义。方法选择144例PCa和100例良性前列腺增生(BPH)患者,取其前列腺组织,采用免疫组化Max Vision法检测ERG蛋白,并分析其与相关临床病理特征的关系。结果 PCa及BPH组织中ERG蛋白的阳性表达率分别为25.0%和0,两者比较,P0.01;PCa组织中ERG蛋白表达与患者的年龄、术前前列腺特异性抗原值及远处转移无关(P均0.05),与Gleason评分呈负相关(r=-0.175,P0.05),Gleason评分≤7分组ERG蛋白表达率高于Gleason评分7分组(P0.05)。结论PCa患者前列腺癌组织中ERG蛋白表达升高,ERG蛋白的检测可能有助于PCa患者的鉴别诊断及病理分级。
[Abstract]:Objective to observe the expression of ERG protein in prostate cancer (PCA) tissues and explore its significance. Methods 144 patients with PCa and 100 patients with benign prostatic hyperplasia (BPH) were selected. ERG protein was detected by immunohistochemical Max Vision method. Results the positive expression rates of ERG protein in PCa and BPH were 25.0% and 0 respectively (P 0.01). The expression of ERG protein in PCa was not correlated with age, prostate specific antigen and distant metastasis (P 0.05). There was a negative correlation with Gleason score (P 0.05). The expression rate of ERG protein in Gleason 鈮，

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