感染性肾结石患者血清及尿液细胞因子的变化观察

发布时间：2018-01-30 18:55

本文关键词： 感染性肾结石血清尿液细胞因子　出处：《中华医院感染学杂志》2017年22期 　论文类型：期刊论文

【摘要】：目的观察感染性肾结石患者血清及尿液细胞因子的变化情况。方法选取2013年9月-2015年10月医院收治的46例感染性肾结石患者为试验组,选取同期46名健康体检人员为对照组,比较两组血清及尿液细胞因子水平,并比较试验组中不同白细胞水平及肾积水情况患者血清及尿液细胞因子水平。结果试验组患者的血清及尿液IL-2水平分别为(10.31±1.56)ug/L及(4.63±0.66)ug/L,均低于对照组的(15.64±2.21)ug/L及(7.86±1.51)ug/L,而血清及尿液其他细胞因子IL-6、IL-10、EGF、IFN-γ及TNF-α水平分别为(7.84±1.14)pg/ml、(24.33±2.50)pg/ml、(763.64±45.98)pg/ml、(16.83±1.54)ug/ml、(1.94±0.22)ng/ml及(4.25±0.65)pg/ml、(11.31±1.54)pg/ml、(342.52±20.68)pg/ml、(7.97±1.18)ug/ml、(1.12±0.15)ng/ml,均高于对照组(3.40±0.52)pg/ml、(11.51±1.56)pg/ml、(410.55±32.52)pg/ml、(7.93±0.73)ug/ml、(0.88±0.12)ng/ml及(1.31±0.20)pg/ml、(5.45±0.64)pg/ml、(195.35±14.63)pg/ml、(3.87±0.52)ug/ml、(0.40±0.05)ng/ml,试验组中白细胞升高及存在肾积水患者的血清及尿液IL-2均低于白细胞未升高及无肾积水患者,血清及尿液其他细胞因子均高于白细胞未升高及无肾积水患者,以上比较差异均有统计学意义(P0.05)。结论感染性肾结石患者血清及尿液细胞因子的变化明显,且受白细胞水平及肾积水的影响,应重视对患者上述血清及尿液指标的监测。
[Abstract]:Objective to observe the changes of serum and urine cytokines in patients with infectious renal calculi. Methods 46 patients with infectious renal calculi from September 2013 to October 2015 were selected as experimental group. The levels of serum and urine cytokines were compared between the control group and 46 healthy persons in the same period. The levels of serum and urine cytokines in patients with hydronephrosis and leukocytes were compared. Results the serum and urine IL-2 levels of patients in the test group were 10.31 卤1.56 respectively. Ug/L and 4. 63 卤0. 66g / L. All of them were lower than those of control group (15.64 卤2.21g / L and 7.86 卤1.51g / L, respectively), while the other cytokines in serum and urine were IL-6 and IL-10 EGF. The levels of IFN- 纬 and TNF- 伪 were 7.84 卤1.14 PG / ml and 24.33 卤2.50 g / ml, respectively. 763.64 卤45.98 g / ml, 16.83 卤1.54 g / ml. 1.94 卤0.22 ng / ml and 4.25 卤0.65 ng / ml, 11.31 卤1.54 g / ml respectively. 342.52 卤20.68 g / ml 7.97 卤1.18 g / ml 1.12 卤0.15 ng / ml. It was higher than that of the control group (3.40 卤0.52g / ml, 11.51 卤1.56g / ml, 410.55 卤32.52g / ml). 7.93 卤0.73 g / ml 0.88 卤0.12 ng / ml and 1.31 卤0.20 g / ml and 5.45 卤0.64 g / ml respectively. 195.35 卤14.63 g / ml 3.87 卤0.52g / ml 0.40 卤0.05 ng / ml. The serum and urine IL-2 of patients with elevated leukocyte and hydronephrosis were lower than that of patients without hydronephrosis. Other cytokines in serum and urine were higher than those in patients with no leucocyte elevation and no hydronephrosis. Conclusion the changes of serum and urine cytokines in patients with infectious renal calculi are obvious and affected by leucocyte level and hydronephrosis. Attention should be paid to the monitoring of the serum and urine indicators mentioned above.
【作者单位】：浙江省丽水市人民医院泌尿外科;
【基金】：浙江省丽水市卫生局基金资助项目(2015lS282)
【分类号】：R692.4
【正文快照】： 感染性肾结石可导致患者肾脏及周围感染,且患者在治疗过程中因感染的存在可导致并发症增多并影响治疗效果,国内外感染性肾结石相关的研究较多见,而细胞因子作为与机体感染状态密切相关的指标[1],对本类指标在感染性肾结石中的表达变化研究则显得尤为必要,而本病作为泌尿系疾病

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