肾脏原发性鳞状细胞癌5例临床病理学分析

发布时间：2018-02-05 02:52

本文关键词： 肾肿瘤鳞状细胞癌原发性临床病理特征　出处：《临床与实验病理学杂志》2015年04期 　论文类型：期刊论文

【摘要】：目的探讨肾脏原发性鳞状细胞癌临床病理学特征、诊断、鉴别诊断、治疗及预后。方法回顾性分析5例肾脏原发性鳞状细胞癌的临床表现、组织学形态和免疫表型特征,并复习相关文献。结果 5例均为男性,平均年龄54.3岁,其中2例伴有肾盂结石。镜下见癌细胞呈巢状、片状排列,部分癌巢周边细胞呈栅栏状排列,可见细胞间桥及角化珠,伴有坏死。免疫表型:癌细胞CK5/6和p63均(+)、EMA(灶状+),CK20、CK7和vimentin均(-)。结论肾脏原发性鳞状细胞癌较少见,可能来源于化生性癌或起源于肾原基的未分化干细胞。免疫组化染色可辅助确诊,其恶性程度比肾透明细胞癌高,预后差。
[Abstract]:Objective to investigate the clinicopathological features, diagnosis, differential diagnosis, treatment and prognosis of primary renal squamous cell carcinoma. Results all 5 cases were male with an average age of 54.3 years, 2 of them were accompanied with renal pelvis stones. Some of the cells around the cancer nest were arranged in a palisade shape with intercellular bridges and keratinized beads accompanied by necrosis. Immunophenotype: CK5/6 and p63 of cancer cells were both (EMA). Conclusion Primary squamous cell carcinoma of the kidney is rare and may be derived from metaplastic carcinoma or undifferentiated stem cells derived from the renal primordium. Immunohistochemical staining may assist in the diagnosis of renal squamous cell carcinoma. Its malignant degree is higher than renal clear cell carcinoma, the prognosis is poor.
【作者单位】：山东省肥城矿业中心医院病理科;济南军区总医院病理科;
【分类号】：R737.11
【正文快照】： 肾脏原发性鳞状细胞癌较少见,国内外文献报道较少,其组织学起源尚存争议,临床易误诊[1]。本文回顾性分析5例肾脏原发性鳞状细胞癌的临床表现、组织学形态和免疫表型特征,并复习相关文献,旨在提高认识水平。1材料与方法1.1临床资料收集2009~2013年肥城矿业中心医院诊治的2例肾

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