Klotho——慢性肾脏病的心血管保护因子

发布时间：2018-02-06 00:59

  本文关键词： 慢性肾脏病 Klotho 心血管　出处：《肾脏病与透析肾移植杂志》2016年01期 　论文类型：期刊论文

【摘要】：Klotho是一种抗衰老基因。既往研究表明,Klotho不仅具有抗衰老作用,还有保护肾脏的作用。近年研究表明,Klotho蛋白具有激素样作用,除可在肾脏局部发挥作用外,还可作用于远端器官(如心血管系统)。慢性肾脏病患者常死于心血管疾病。由于Klotho高表达于肾脏且可作用于远端器官,因此,Klotho对慢性肾脏病相关心血管病变的作用成为近年研究热点。本文就Klotho对慢性肾脏病合并心血管病变的影响进行综述。
[Abstract]:Klotho is an anti-aging gene. Previous studies have shown that Klotho not only has anti-aging effect, but also protects kidney. Klotho protein has a hormone like effect, except for the local role in the kidney. Chronic kidney disease patients often die of cardiovascular disease. Because Klotho is highly expressed in the kidney and can act on the distal organ, so. The effect of Klotho on cardiovascular disease associated with chronic kidney disease has become a hot topic in recent years. This article reviews the effects of Klotho on cardiovascular disease associated with chronic kidney disease.
【作者单位】： 南京军区南京总医院肾脏科国家肾脏疾病临床医学研究中心全军肾脏病研究所;
【分类号】：R692
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本文编号：1493200