大、小Y染色体携带者精液参数及辅助生殖结局分析

发布时间：2018-02-11 13:34

本文关键词： 大Y染色体小Y染色体精液参数 ART结局　出处：《中华男科学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的:探讨Y染色体长度异常对精液参数以及对ART结局的影响,以期为临床工作提供指导。方法:963例辅助生育患者按Y染色体长度分为正常对照组(n=854),Y18组(n=24)及Y22组(n=85),并将Y18组和Y22组的精液参数及在ART过程中的胚胎数及优质胚胎数与正常对照组进行比较。用χ~2检验及t检验进行统计学分析。结果:Y18组中弱精子症患者比例明显低于正常对照组(8.33%vs 31.03%),优质胚胎数较对照组多,差异均有显著性(P0.05);Y22组中无精子症比例明显高于正常对照组(16.47%vs 1.87%),在ICSI过程中胚胎数多于正常对照组,差异均有显著性(P0.05),Y18和Y22两组妊娠率与对照组统计学差异均无显著性(P0.05)。结论:小Y染色体可能对精子发生有影响,而携带大、小Y染色体不会降低ART的妊娠率。因此,对于大、小Y染色体携带不育患者,进行辅助生殖技术可获得和正常核型类似的妊娠结局。
[Abstract]:Objective: to investigate the effect of abnormal Y chromosome length on semen parameters and ART outcome. Methods: a total of 963 assisted fertility patients were divided into two groups according to Y chromosome length: normal control group (n = 854) and Y22 group (n = 85). The semen parameters of group Y18 and group Y22 and the number of embryos in the process of ART and the number of high quality embryos in group Y18 and Y22 were analyzed. Results the proportion of asthenospermia in the group of 20% Y18 was significantly lower than that in the control group (8.33 vs 31.033%), and the number of high-quality embryos was higher than that in the control group. The percentage of azoospermia was significantly higher in the P0.05TY22 group than in the normal control group (16.47 vs 1.87), and the number of embryos in the ICSI process was higher than that in the normal control group. There was no significant difference in pregnancy rate between the two groups. Conclusion: the small Y chromosome may have an effect on spermatogenesis, but the small Y chromosome does not decrease the pregnancy rate of ART. Small Y chromosomes carry infertile patients, and assisted reproductive techniques can obtain pregnancy outcomes similar to normal karyotypes.
【作者单位】：青海省人民医院生殖医学中心;
【基金】：青海省基础研究计划项目应用基础研究(2016-ZJ-750)~~
【分类号】：R698.2

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