儿童心脏死亡器官捐献供者单肾成人肾移植的疗效

发布时间：2018-02-12 15:43

本文关键词： 心脏死亡器官捐献儿童供者单肾成人移植　出处：《实用医学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的:观察儿童心脏死亡器官捐献(DCD)供者单肾成人移植的早期临床疗效。方法:回顾性分析广东省第二人民医院器官移植中心2010年1月至2016年5月儿童DCD供者单肾成人移植供、受者临床资料。6例儿童DCD供者中位年龄9岁(5~15岁),均捐献给相同血型受者。12例受者中位年龄38岁(21~65岁),男4例,女8例,均为首次肾移植,群体反应性抗体均阴性,HLA错配数1~4个。均采用右侧髂窝移植法。结果:12例受者手术均获成功。术后肾功能恢复均较顺利,未发生急性排斥反应、移植肾原发性无功能和移植肾功能延迟。其中5例为移植肾功能5 d内恢复正常,5例为移植肾功能10 d逐步恢复,有2例缓慢恢复。1例受者术后出现尿漏,经通畅引流后尿漏停止。1例受者切口延迟愈合,换药后Ⅱ期愈合。术后随访1~36个月,受者和移植肾全部存活,所有受者肾功能均正常。结论:儿童DCD供者单肾成人移植早期临床疗效良好,是一种扩大供者来源的良好途径。
[Abstract]:Objective: to observe the early clinical effect of single kidney adult transplantation in children with cardiac death organ donation. Methods: from January 2010 to May 2016, the single kidney adult donor of DCD donor was retrospectively analyzed in the center of organ transplantation of the second people's Hospital of Guangdong Province. Clinical data of 6 children with DCD. The median age of donor was 9 years old and 515 years old. All of them were donated to recipients of the same blood group. The median age of 12 recipients was 38 years old or 21 65 years old, male 4 cases, female 8 cases, all of them were first kidney transplantation. The HLA mismatch numbers of all the negative antibodies were 1 ~ 4. The right iliac fossa transplantation was used in all the patients. Results all the 12 recipients were successfully operated. The renal function recovered smoothly and no acute rejection occurred. Primary renal failure and delayed graft function were found in 5 cases, 5 cases of which were normal within 5 days after transplantation, and 2 cases of slow recovery of renal function were found in 1 case of urine leakage after operation. The renal function was recovered gradually in 5 cases within 5 days after transplantation, and in 2 cases, urine leakage occurred in 1 cases. After unobstructed drainage, urinary leakage stopped the delayed healing of the incision in 1 recipient, and healed in the second stage after dressing change. All the recipients and the transplanted kidney survived after 1 ~ 36 months follow-up. Conclusion: the early clinical effect of adult DCD donor transplantation is good, and it is a good way to enlarge donor source.
【作者单位】：广东省第二人民医院器官移植科;
【基金】：广东省医学科学研究基金资助项目(编号:B2016104)
【分类号】：R699.2

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