和络宁风颗粒治疗慢性肾衰竭钙磷代谢紊乱的临床研究

发布时间：2018-02-13 21:17

本文关键词： 慢性肾衰竭钙磷代谢紊乱中医药疗法和络宁风颗粒临床研究　出处：《青岛大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察和络宁风颗粒治疗慢性肾衰竭血液透析伴钙磷代谢紊乱患者的治疗效果,结合现代药理学研究,探寻中医药防治慢性肾衰竭钙磷代谢紊乱更为有效的方法与途径。方法:将符合入选的74例慢性肾衰竭血液透析伴钙磷代谢紊乱患者,随机分为治疗组和对照组,每组37例。对照组患者给予基础治疗,治疗组患者在接受基础治疗的同时,服用和络宁风颗粒。服药2个月为一疗程,共治疗1个疗程。观察患者治疗前后中医证候积分及实验室指标的变化,其中实验室指标包括:血清尿素氮(BUN)、肌酐(Cr)、钙(Ca)、磷(P)、甲状旁腺激素(i PTH)、碱性磷酸酶(ALP)、血红蛋白(HGB)、血清白蛋白(ALB)、前白蛋白(PA)。结果:(1)治疗组总有效率为85.29%,对照组总有效率为66.67%,治疗组优于对照组(P0.05);(2)治疗组患者在控制中医证候积分明显降低,改善临床症状方面优于对照组(P0.01);(3)治疗组患者治疗后血清Ca水平升高,血清P、i PTH、ALP水平降低,疗效优于对照组(P0.05);(4)治疗组患者血HGB、血清ALB、PA升高,疗效优于对照组(P0.05);(5)治疗组患者血清BUN、Cr水平降低,疗效优于对照组(P0.05)。结论:和络宁风颗粒可有效调节慢性肾衰竭钙磷代谢紊乱,改善患者肾功能及营养状况。
[Abstract]:Objective: to observe the therapeutic effect of he Luoning Feng granule on chronic renal failure hemodialysis patients with calcium and phosphorus metabolism disorder, combined with modern pharmacological study. Methods: 74 patients with chronic renal failure were randomly divided into treatment group and control group. There were 37 cases in each group. The patients in the control group were given basic treatment, while the patients in the treatment group were treated with Heloningfeng granule while the patients in the treatment group were treated for 2 months as a course of treatment. Observe the changes of TCM syndromes integral and laboratory indexes before and after treatment. The laboratory indexes include: serum urea nitrogen bun, creatinine, calcium caproxide, phosphorophosphate, parathyroid hormone I PTHN, alkaline phosphatase ALPU, hemoglobin (HGBG), serum albumin (ALBN), prealbumin (PAA). Results the total effective rate of the treatment group was 85.29, and that of the control group was 85.29.The total effective rate of the treatment group was 85.29, and that of the control group was higher than that of the control group. The effective rate was 66.67 and the treatment group was superior to the control group (P0.05P0.05) the score of TCM syndromes in the treatment group was significantly lower than that in the control group. The improvement of clinical symptoms was better than that of the control group (P 0.01). After treatment, the serum Ca level was increased, and the serum Proni PTHU ALP level was decreased in the treatment group. The curative effect was better than that in the control group (P 0.05)) the serum HGBand ALBPA in the treatment group were higher than those in the control group. The therapeutic effect was better than that of the control group (P0.05P0.05)) the serum level of BUN-Cr in the treatment group was lower than that in the control group (P0.050.Conclusion: Horoningfeng granule can effectively regulate the disorder of calcium and phosphorus metabolism in chronic renal failure and improve the renal function and nutritional status of the patients.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R692.5

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