脱细胞基质与肾脏组织工程的应用前景

发布时间：2018-02-14 18:08

本文关键词： 肾细胞外基质组织工程生物材料材料相容性肾脏脱细胞基质种子细胞国家自然科学基金　出处：《中国组织工程研究》2017年10期 　论文类型：期刊论文

【摘要】：背景:研究表明,脱细胞基质材料和合适的种子细胞的有机结合可构建工程化肾脏。目的:综述脱细胞基质和肾脏组织工程的研究进展。方法:由第一作者以"脱细胞基质,细胞外基质,组织工程,肾脏,种子细胞"为中文检索词,以"decellularized matrix,extracellular matrix,tissue engineering,kidney,seeded cells"为英文检索词,在CNKI、万方数据库和Pub Med数据库检索1999年1月至2016年4月的有关肾脏组织工程的文献。结果与结论:脱细胞基质材料由于其去除了细胞成分,失去了免疫原性,同时保留了细胞外基质中重要的生物活性成分及组织器官的超微结构,使得其在肾脏组织工程中越来越受到重视,尤其是在最近新兴的全器官脱细胞技术的推动下,使得其在工程化全肾脏的构建中发挥着重要作用。尽管近年来基于脱细胞基质的肾脏组织工程研究发展迅速,并实现了一定功能的工程化肾脏的构建,但在具有完全肾脏功能的工程化肾脏构建中仍面临着一些列的挑战性问题。
[Abstract]:Background: studies have shown that the organic combination of acellular matrix materials with suitable seed cells can be used to construct engineered kidneys. Objective: to review the progress of acellular matrix and renal tissue engineering. Extracellular matrix, tissue engineering, kidney, seed cell were used as Chinese key words, and "decellularized matrixtissue engineering cells" was used as the English key word. In CNKI, Wanfang database and Pub Med database, literatures on renal tissue engineering were searched from January 1999 to April 2016. Results and conclusions: acellular matrix material lost its immunogenicity because of its removal of cellular components. At the same time, the important bioactive components of extracellular matrix and the ultrastructure of tissues and organs are preserved, which makes it more and more important in renal tissue engineering, especially under the promotion of the newly developed whole organ acellular technology. It plays an important role in the construction of engineered whole kidney, although the research on renal tissue engineering based on acellular matrix has developed rapidly in recent years, and the engineering kidney has achieved certain functions. However, there are still some challenging problems in engineering kidney construction with full renal function.
【作者单位】：南京医科大学附属南京医院(南京市第一医院)泌尿外科;山东省曹县人民医院泌尿外科;
【基金】：国家自然科学基金(31500785)~~
【分类号】：R318.08;R692

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