前列腺癌病例报告及相关生物标记物研究分析

发布时间：2018-02-24 01:14

本文关键词： 前列腺癌病例生物标记物　出处：《兰州大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：通过对临床工作中前列腺癌病例进行分析报道,以及近年前列腺生物标记物做一综述,以更进一步指导本院临床前列腺癌诊治。方法：搜集临床工作中前列腺癌一例,系统分析其住院期间诊治过程：利用Pubmed、Web of science、万方、维普等文件搜索数据库搜索近国内外近两年关于前列腺癌生物标记物的最新研究进展,阅读文献后对其进行归纳总结,并编写综述一篇。结果：通过对本院前列腺癌的诊治经过分析,结合国内外诊治现状,发现目前前列腺早期诊断率较低,而人类激肽释放酶(human kallikreins hk).前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)、早期前列腺癌抗原(early prostate cancer antigen,EPCA)及EPCA-2.5α-甲酰基辅酶A消旋酶(a-methylacyl CoA racemase,AMACR或称P504S)、PCA3、肌氨酸、Engrailed-2及血红素氧化酶-1等在PCa早期诊断中有较高的应用价值。
[Abstract]:Objective: to analyze and report the cases of prostate cancer in clinical work and to review the biomarkers of prostate cancer in recent years in order to further guide the diagnosis and treatment of prostate cancer in our hospital. Methods: one case of prostate cancer in clinical work was collected. The process of diagnosis and treatment during hospitalization was systematically analyzed. The latest research progress of prostate cancer biomarkers in recent two years was searched by Pubmedan Web of Science, Wanfang, Wiper and so on. After reading the literature, the biomarkers of prostate cancer were summarized and summarized. Results: through the analysis of the diagnosis and treatment of prostate cancer in our hospital and the present situation of diagnosis and treatment at home and abroad, we found that the early diagnosis rate of prostate is relatively low. Specific membrane antigen-PSMAA, early prostate cancer antigen-EPCAA), EPCA-2.5 伪 -methylacyl CoA racemase- AMACR or P504SPCA3, sarcosine Engrailed-2 and heme oxygenase--1 were found in the early stage of PCa. It has high application value in diagnosis.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.25

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