益气温阳活血利水方辅助治疗心肾综合征60例临床观察

发布时间：2018-03-02 11:41

本文选题：心肾综合征　切入点：益气温阳活血利水方　出处：《中医杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的观察益气温阳活血利水方辅助治疗心肾综合征的临床疗效。方法 123例心肾综合征患者随机分为治疗组62例和对照组61例,对照组采用西医对症治疗,治疗组在对照组治疗基础上加用益气温阳活血利水方口服,每日1剂,两组疗程均为20天。疗程结束后观察两组患者临床疗效、心功能改善情况、内生肌酐清除率(Ccr),利尿剂使用剂量及不良反应。结果治疗组临床疗效总有效率为83.33%,对照组总有效率为61.67%,治疗组高于对照组(P0.01)。治疗组治疗后较治疗前心脏射血分数(EF)及Ccr均明显提高(P0.01),对照组治疗前后比较差异均无统计学意义(P0.05)。疗程结束后,治疗组原口服联合静脉利尿剂47例患者静脉利尿剂的剂量较治疗前减半或者停用,原单纯口服利尿剂的13例患者较治疗前剂量减半;对照组60例使用利尿剂的剂量治疗前后差异无统计学意义(P0.05)。对照组治疗过程中,患者出现不同程度的电解质紊乱(40例)、利尿剂抵抗(32例)及脂代谢紊乱(25例);而治疗组中出现轻度电解质紊乱(20例)、利尿剂抵抗(15例),治疗组不良反应明显少于对照组(P0.01)。结论益气温阳活血利水方辅助治疗心肾综合征能提高临床疗效,且能明显减少西药所致的不良反应。
[Abstract]:Objective to observe the clinical efficacy of Yiyanghuoxue Lishui recipe in the treatment of cardiorenal syndrome. Methods 123 patients with cardiorenal syndrome were randomly divided into treatment group (n = 62) and control group (n = 61). On the basis of the treatment in the control group, the treatment group was given orally Yiyanghuoxue Lishui decoction, one dose per day, both for 20 days. After the treatment, the clinical curative effect and the improvement of cardiac function were observed in the two groups. Results the total effective rate was 83.33 in the treatment group and 61.67 in the control group, which was higher than that in the control group. The heart ejection fraction in the treatment group was higher than that in the pre-treatment group. There was no significant difference between the control group and the control group before and after treatment (P 0.05). After the end of the course of treatment, there was no significant difference between the two groups. In the treatment group, the dosage of intravenous diuretic was halved or stopped before treatment in 47 patients with oral diuretic, and the dosage of diuretic was halved in 13 patients with oral diuretic alone. In the control group, there was no significant difference in the dose of diuretic before and after treatment (P 0.05). There were 40 cases of electrolyte disorder, 32 cases of diuretic resistance and 25 cases of dyslipidemia in the treatment group, while in the treatment group, there were 20 cases of mild electrolyte disorder and 15 cases of diuretic resistance. The adverse reactions in the treatment group were significantly less than those in the treatment group. Conclusion Yiyanghuoxue Lishui prescription can improve the clinical effect of cardiorenal syndrome. And can obviously reduce the adverse reaction caused by western medicine.
【作者单位】：河北省唐山市中医医院;
【基金】：河北省中医药管理局科研计划(2014248)
【分类号】：R541.6;R692

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