激素敏感转移性前列腺癌预后因素分析

发布时间：2018-03-06 05:28

本文选题：激素敏感性前列腺癌　切入点：去势抵抗性前列腺癌　出处：《中国现代医学杂志》2015年03期 　论文类型：期刊论文

【摘要】：目的探寻影响激素敏感转移性前列腺癌进展为去势抵抗性前列腺癌(CRPC)的预测因子。方法纳入北京积水潭医院2006年6月-2014年6月收治的50例激素敏感转移性前列腺癌患者。收集此50例患者的临床和病理资料,并对这些患者进行规律门诊和住院随访。将临床病理资料以及患者的预后数据采用SPSS16.0统计软件进行分析。生存函数分析运用Kaplan-Meier法,单因素和多因素分析运用Cox回归,并采用Log-rank法进行显著性检验。结果末次随访时间为2014年10月31日,中位随访时间34(9~83)个月。随访期间有17例患者进展为CRPC。患者内分泌治疗无进展生存时间曲线结果显示:患者的中位无进展生存时间为34(9~83)个月,1、2及3年无进展生存率分别为84%、58%及42%。单因素和多因素分析结果显示:Gleason评分(P=0.003)、基线PSA值(P=0.049)、碱性磷酸酶(P=0.021)、四肢骨转移(P=0.005)、内脏转移(P=0.006)为激素敏感转移性前列腺癌进展为CRPC的独立预后因素。结论 Gleason评分、基线PSA、碱性磷酸酶、四肢骨转移及内脏转移为激素敏感转移性前列腺癌进展为CRPC的独立预测因子。
[Abstract]:Objective to explore the prognostic factors influencing the progression of steroid sensitive metastatic prostate cancer as castrated resistant prostate cancer (CRPC). Methods 50 cases of steroid-sensitive metastatic prostate were admitted to Beijing Jishuitan Hospital from June 2006 to June 2014. The clinical and pathological data of these 50 patients were collected, The clinicopathological data and prognosis data were analyzed by SPSS16.0 software. Survival function analysis was performed by Kaplan-Meier method, single factor analysis and multivariate analysis by Cox regression. The significance test was performed by Log-rank method. Results the last follow-up time was October 31st 2014. The median follow-up time was 34 ~ 9 / 83 months. During the follow-up period, 17 patients progressed to CRPC.Results showed that the median progression-free survival time of the patients was 34 / 9 / 83) / 1 / 2 and 3 years' progression-free survival rate. The results of univariate and multivariate analysis showed that the ratio of 1: Gleason score, baseline PSA, alkaline phosphatase, bone metastases, visceral metastasis and visceral metastasis were independent prognostic factors of CRPC. Conclusion the results of univariate and multivariate analysis showed that the baseline PSA was 0.049, alkaline phosphatase was 0.021, bone metastases of extremities P0.005 and visceral metastases P0.006) were independent prognostic factors for the progression of steroid-sensitive metastatic prostate cancer. Baseline psa, alkaline phosphatase, bone metastasis of extremities and visceral metastasis were independent predictors of the progression of steroid-sensitive metastatic prostate cancer to CRPC.
【作者单位】：北京积水潭医院泌尿外科;
【分类号】：R737.25

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