抗中性粒细胞胞质抗体相关性肾炎组织学分型的研究进展

发布时间：2018-03-07 02:29

本文选题：抗中性粒细胞胞质抗体相关性肾炎　切入点：组织病理学分型　出处：《医学研究生学报》2017年10期 　论文类型：期刊论文

【摘要】：抗中性粒细胞胞质抗体(ANCA)相关性肾炎是急进型肾小球肾炎最常见的原因,肾活检是确诊本病的金标准。肾活检病理检查在制定ANCA相关性肾炎治疗方案和判断预后中具有重要临床价值,但ANCA相关性肾炎的病理学分型在很长时间内未达成共识。2010年制定的ANCA相关性肾炎病理分型标准(EUVAS分型)将其分为局灶型、新月体型、混合型以及硬化型。随后有多项研究证实此分型对ANCA相关性肾炎肾预后的预测价值。但不同研究中各种病理类型的肾存活率差异显著,ANCA相关性肾炎病理分型对治疗的指导价值及更精确判断预后仍需进一步研究。文章主要就ANCA相关性肾炎最新病理分型的临床意义、相关病理特征定义及该分型的相关验证研究进行综述。
[Abstract]:Anti-neutrophil cytoplasmic antibody (ANCA) -associated glomerulonephritis is the most common cause of acute glomerulonephritis. Renal biopsy is the gold standard for the diagnosis of this disease. The pathological examination of renal biopsy has important clinical value in formulating the treatment scheme of ANCA associated glomerulonephritis and judging the prognosis. However, the pathological classification of ANCA associated glomerulonephritis did not reach consensus for a long time. In 2010, ANCA associated glomerulonephritis was classified as focal type and crescent type. Mixed type and sclerosing type. Subsequently, several studies confirmed the value of this classification in predicting the renal prognosis of ANCA associated glomerulonephritis. However, there were significant differences in renal survival rate among different pathological types of ANCA-associated glomerulonephritis in different studies. The clinical significance of the latest pathological classification of ANCA associated glomerulonephritis needs to be further studied. The definition of relevant pathological features and the relevant validation of the classification were reviewed.
【作者单位】：南京军区南京总医院国家肾脏疾病临床医学研究中心全军肾脏病研究所;
【基金】：国家科技支撑计划课题(2013BAI09B04,2015BAI12B05) 江苏省临床医学中心项目(BL2012007)
【分类号】：R692.3

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