肾脏黏液样小管状和梭形细胞癌5例临床病理分析

发布时间：2018-03-07 05:13

本文选题：肾脏肿瘤　切入点：黏液样小管状和梭形细胞癌　出处：《临床与实验病理学杂志》2015年12期 　论文类型：期刊论文

【摘要】：目的探讨肾脏黏液样小管状和梭形细胞癌(mucinous tubular and spindle cell carcinoma,MTSCC)的临床病理学特征、免疫表型、治疗及预后。方法回顾性分析5例肾脏MTSCC患者资料,4例女性,1例男性,平均年龄50岁;腰痛2例,体检发现肾肿瘤3例。结果肿瘤最大径范围3.3~6.5 cm,平均4.86 cm。发生于右侧3例,左侧2例。2例行肿瘤剜除术,3例行根治性肾切除术。肿瘤均位于肾实质内,界限清楚。3例为经典型,1例富于管状结构,1例富于梭形细胞。此外,含有比例不等的泡沫细胞、透明细胞、乳头状结构及坏死区域。细胞核无多形性,无核分裂象。免疫组化标记CD10、CD15、CK7、CK19、EMA、AMACR的阳性率分别为0、20%、80%、80%、100%、100%。术后平均随访时间38.6个月,均存活。结论 MTSCC是一种少见的低度恶性肿瘤,其预后较好。诊断主要依据病理形态学特征及免疫表型。治疗主要为手术切除。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype, treatment and prognosis of mucinous tubular and spindle cell carcinoma of renal mucous tubular and spindle cell carcinoma. There were 2 cases of low back pain, 3 cases of renal tumor were found by physical examination. Results the maximum diameter of the tumor was 3. 3 卤6. 5 cm, with an average of 4. 86 cm. The tumor occurred in 3 cases on the right side, 2 cases on the left side, and 3 cases on radical nephrectomy with enucleation of the tumor. The tumors were located in the renal parenchyma. In addition, there were foam cells, transparent cells, papillary structures and necrotic areas in different proportions. The nuclei had no pleomorphism. The positive rate of EMA-AMACR with immunohistochemical marker CD10, CD15, CK7, CK19 and EMA-AMACR was 0.20, 8080, 100 and 100, respectively. The average follow-up time was 38.6 months and all survived. Conclusion MTSCC is a rare low-grade malignant tumor. The prognosis was good. The diagnosis was mainly based on pathomorphological features and immunophenotypes. Surgical resection was the main treatment.
【作者单位】：浙江省嵊州市人民医院病理科;浙江省湖州市中心医院病理科;
【分类号】：R737.11

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