早期糖尿病肾病血清NGAL与致动脉硬化指数的关系

发布时间：2018-03-09 00:33

本文选题：糖尿病肾病　切入点：中性粒细胞明胶酶相关载脂蛋白　出处：《中国动脉硬化杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的观察在早期糖尿病肾病(DN)患者血清中性粒细胞明胶酶相关载脂蛋白(NGAL)水平的变化,探讨NGAL与致动脉硬化指数(AIP)的关系。方法选取尿微量白蛋白/肌酐300 mg/g的糖尿病患者120例为糖尿病组,根据尿微量白蛋白/肌酐分为正常白蛋白尿组和早期DN组,另选取健康体检者60例作为对照组。检测各组血清甘油三酯(TG)、胆固醇(CHOL)、高密度脂蛋白(HDL)、NGAL、超敏C反应蛋白(hs-CRP)等,并计算致动脉硬化指数;分析3组NGAL、hs-CRP、AIP的变化。按照AIP三分位数将所有研究对象分成低、中、高水平3组,分析其NGAL和hs-CRP的变化。对所有变量进行简单线性相关和多元线性逐步回归分析。结果与对照组比较,正常白蛋白尿组和早期DN组NGAL、hs-CRP、AIP水平明显升高(P0.001);与正常白蛋白尿组比较,早期DN组NGAL、hs-CRP、AIP水平明显升高(P0.001)。血清NGAL水平随AIP上升而明显上升(P0.001)。AIP与hsCRP、NGAL呈正相关(r=0.296,0.313,P0.05);NGAL、hs-CRP为AIP的独立影响因素。结论血清NGAL是监测糖尿病早期肾损伤的指标。NGAL是一个急性时相反应蛋白,参与了糖尿病肾病动脉粥样硬化的发生发展。
[Abstract]:Objective to observe the changes of serum neutrophil gelatinase-associated apolipoprotein (apolipoprotein) NGALs in patients with early diabetic nephropathy (DN). To investigate the relationship between NGAL and atherosclerosis index (AIP). Methods 120 diabetic patients with urinary microalbuminuria / creatinine 300 mg/g were selected as diabetic group and divided into normal albuminuria group and early DN group according to urinary microalbumin / creatinine. In addition, 60 healthy persons were selected as control group. Serum triglyceride triglyceride (TGG), cholesterol Choll (CHOLL), high density lipoprotein (HDL) NGALs, hypersensitive C-reactive protein hs-CRP( hs-CRP) were detected and arteriosclerosis index was calculated. The changes of AIP hs-CRP AIP in three groups were analyzed. All the subjects were divided into three groups: low, middle and high levels according to the three-digit number of AIP. The changes of NGAL and hs-CRP were analyzed. A simple linear correlation and multiple linear stepwise regression analysis were carried out on all variables. Results compared with the control group, the levels of NGAL and hs-CRP in normal albuminuria group and early DN group were significantly higher than those in normal albuminuria group and early DN group, and those in normal albuminuria group were significantly higher than those in normal albuminuria group. The serum NGAL level was significantly increased with the increase of AIP in early DN group. There was a positive correlation between serum NGAL level and hsCRPnNGAL. Conclusion Serum NGAL is an acute phase reaction protein for early diabetic renal injury, and it is a positive correlation between NGALHs-CRP and hsCRPnNGAL. Participate in the development of diabetic nephropathy atherosclerosis.
【作者单位】：河北省人民医院检验科;石家庄市第二医院检验科;
【基金】：河北省医学科学研究重点课题(20160080)
【分类号】：R587.1;R692.9

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