膀胱过度活动症患者脑~1H-MRS成像特点及临床相关分析

发布时间：2018-03-16 05:10

本文选题：膀胱过度活动症　切入点：磁共振波谱成像　出处：《首都医科大学学报》2017年06期 　论文类型：期刊论文

【摘要】：目的利用氢质子磁共振波谱(proton magnetic resonance spectroscopy,1H-MRS)成像探讨膀胱过度活动症(overactive bladder,OAB)患者特定脑区的代谢变化。方法选择临床确诊的膀胱过度活动症患者23例,健康志愿者23例,记录所有受试者的抑郁自评量表(Self-rating Depression Scale,SDS)评分及患者的膀胱过度活动症患者自我评价量表(Overactive Bladder Symptom Score,OABSS)评分。所有受试者接受颅脑多体素1H-MRS扫描,并利用专用的后处理软件计算双侧额叶前部、中部、后部及双侧扣带回前部、后部的N-乙酰基天门冬氨酸(N-acetyl aspartate,NAA)/磷酸肌酸(creatine,Cr)、胆碱化合物(choline,Cho)/Cr比值,进行组间比较。并且,利用Pearson相关系数对NAA/Cr、Cho/Cr比值与SDS、OABSS评分进行相关分析。结果 OAB患者双侧额叶前部、右侧额叶中部、双侧前扣带回、左侧后扣带回的NAA/Cr值较对照组降低,其余指标差异无统计学意义(P0.05)。OAB组右侧额叶中部NAA/Cr比值与SDS评分呈负相关(r=-0.361,P0.05)。结论~1H-MRS能够反映OAB患者的脑部代谢变化,为进一步的治疗提供理论依据。
[Abstract]:Objective to investigate the metabolic changes in specific brain regions of patients with overactive bladder hyperactivity by using proton magnetic resonance spectroscopy1H-MRS imaging. Methods 23 patients with bladder hyperactivity and 23 healthy volunteers were selected. The self-rating Depression scale (SDSs) scores of all subjects and the overactive Bladder Symptom ScoreBSS scores of patients with bladder hyperactivity were recorded. All subjects were scanned with craniocerebral multivoxel 1H-MRS. The ratio of N-acetyl aspartate NAAU / creatine creatine (Cr), choline compound (choline) in the anterior part, middle part, posterior part and anterior cingulate gyrus of bilateral frontal lobe, middle part, posterior cingulate gyrus and posterior part of the frontal lobe were calculated by the special post-processing software, and the comparison was made between the two groups, and the results showed that the ratio of N-acetyl aspartate NAAU / creatine creatine cr, choline compound was compared between the two groups. Pearson correlation coefficient was used to analyze the correlation between the ratio of NAA / Cr / Cr and the score of OAB. Results the NAA/Cr values of bilateral frontal lobe, right middle frontal lobe, bilateral anterior cingulate gyrus and left posterior cingulate gyrus were lower in OAB patients than those in control group. There was no significant difference in the other indexes. There was a negative correlation between the ratio of NAA/Cr in the middle frontal lobe of right side and the SDS score. Conclusion 1H-MRS can reflect the changes of brain metabolism in patients with OAB, and provide a theoretical basis for further treatment.
【作者单位】：首都医科大学附属北京朝阳医院放射科;首都医科大学附属北京朝阳医院泌尿外科;
【基金】：国家自然科学基金(81541129)~~
【分类号】：R445.2;R694

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