重组人表皮生长因子凝胶在尿道下裂术后尿瘘中的应用效果观察

发布时间：2018-03-16 17:39

本文选题：尿道下裂　切入点：尿瘘　出处：《河北医药》2015年09期 　论文类型：期刊论文

【摘要】：目的探讨重组人表皮生长因子(rh EGF)凝胶在尿道下裂术后尿瘘早期处理中的应用效果。方法将2011年9月至2014年7月行尿道下裂手术后出现的44例尿瘘患者随机分为2组,2组患者在给予留置尿管、常规创面换药及对症处理的基础上,试验组瘘口表面应用rh EGF凝胶,对照组瘘口表面涂以0.9%氯化钠溶液,观察2组尿瘘愈合情况。结果试验组共愈合14例,总愈合率63.64%,其中大瘘口愈合9例,小瘘口愈合5例;对照组共愈合5例,总愈合率22.73%,其中大瘘口仅愈合2例,小瘘口愈合3例。与对照组比较,试验组总愈合率和大瘘口的愈合率明显提高,差异有统计学意义(P0.05),而小瘘口的愈合率略高于对照组,但差异无统计学意义(P0.05)。结论尿道下裂术后尿瘘早期及时处理,小瘘口大部分能够愈合,应用rh EGF凝胶对瘘口愈合具有促进作用。
[Abstract]:Objective to investigate the effect of recombinant human epidermal growth factor rh EGF gel on early management of urethral fistula after hypospadias surgery. Methods 44 patients with urethral fistula who underwent hypospadias surgery from September 2011 to July 2014 were randomly divided into two groups:. Two groups of patients were given indwelling catheter, On the basis of routine dressing change and symptomatic treatment, rh EGF gel was used on the surface of the fistula in the experimental group and 0.9% sodium chloride solution was applied on the surface of the fistula in the control group. The total healing rate was 63.64, including 9 cases of large fistula healing, 5 cases of small fistula healing, 5 cases of total healing rate of the control group and 22.73% of total healing rate, of which only 2 cases of big fistula and 3 cases of small fistula healed. The total healing rate of the experimental group and the healing rate of the large fistula were significantly higher than those of the control group (P 0.05), but the healing rate of the small fistula was slightly higher than that of the control group, but the difference was not statistically significant (P 0.05). Conclusion the early and timely treatment of urinary fistula after hypospadias surgery is significant. Most of the small fistula can heal, and the application of rh EGF gel can promote the healing of fistula.
【作者单位】：河北医科大学第二医院泌尿外科;
【分类号】：R726.9

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