乙肝相关性肾炎的研究进展

发布时间：2018-03-17 13:53

本文选题：乙肝相关性肾炎　切入点：病理类型　出处：《南昌大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过分析乙肝相关性肾炎的临床表现、病理类型、诊断、发病机制及治疗方法等分析及研究来探索乙肝相关性肾炎(Hepatitis B virus associated glomerulonephritis,HBV-GN)的研究进展。方法:利用计算机检索筛选关于乙肝相关性肾炎各个方面研究以及抗乙肝病毒(HBV)治疗临床研究的文献。结果:检索出多篇关于乙肝相关性肾炎诊断、临床表现、病理、发病机制及治疗方法研究的文献,通过阅读这些文献及查阅相关参考资料,进行归纳总结得出关于乙肝相关性肾炎的最新研究进展。结论:乙肝相关性肾炎的发病主要与机体内相关免疫复合物的沉积、HBV病毒对肾脏的损伤及相关免疫介导的损害等发病机制有关。相关研究发现乙型肝炎病毒感染损伤与导致HBV-GN之间的关系,而清除乙肝病毒抗原、抑制乙肝病毒DNA复制治疗目的在于改善尿蛋白、延缓肾功能进展。在针对HBV-GN的治疗上多考虑以抗HBV病毒为主,联合适当剂量的激素或其他新型免疫抑制剂治疗。因此早期识别HBV-GN和及时抗病毒及免疫抑制治疗HBV-GN至关重要。
[Abstract]:Objective: to analyze the clinical manifestations, pathological types and diagnosis of hepatitis B associated glomerulonephritis. To explore the research progress of HBV-GNN in hepatitis B virus associated conglomerate glomerulonephritis.Methods: computer search was used to screen all aspects of hepatitis B associated glomerulonephritis and anti-hepatitis B virus. Results: several articles on the diagnosis of hepatitis B associated glomerulonephritis were retrieved. Literature on clinical manifestations, pathology, pathogenesis and treatment, by reading these documents and consulting relevant reference materials, Conclusion: the pathogenesis of hepatitis B associated glomerulonephritis is mainly related to the deposition of immune complex in the body and the damage of HBV virus to the kidney and related immune mediations. Related studies have found the relationship between hepatitis B virus infection and HBV-GN. The purpose of eliminating hepatitis B virus antigen and inhibiting hepatitis B virus DNA replication is to improve urine protein and delay the progress of renal function. In combination with appropriate doses of hormones or other new immunosuppressants, early identification of HBV-GN and timely antiviral and immunosuppressive treatment of HBV-GN are essential.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R512.62;R692.3

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