成人特发性膜性肾病血清抗M型磷脂酶A2受体抗体与病情的相关性研究

发布时间：2018-03-18 14:38

本文选题：特发性膜性肾病　切入点：酶联免疫反应　出处：《中国现代医学杂志》2016年09期 　论文类型：期刊论文

【摘要】：目的通过研究成人特发性膜性肾病(IMN)血清抗M型磷脂酶A2受体(PLA2R)抗体的阳性滴度与其他实验室指标的相关性,进一步探讨抗PLA2R抗体对IMN诊断及病情评估的作用。方法选取B超引导下肾穿刺活检证实为IMN患者55例,追踪观察6个月,同时选取15例健康体检者为对照组,应用酶联免疫吸附法(ELISA)检测血清抗PLA2R抗体,同时对IMN患者24 h尿蛋白定量、血清总蛋白、血清白蛋白、血清总胆固醇、血清肌酐进行检测。结果经过3和6个月治疗后,血清抗PLA2R抗体较治疗前降低(P0.05)。55例IMN患者治疗前血清抗PLA2R抗体阳性患者47例,阳性率为85.45%;治疗3个月后血清抗PLA2R抗体阳性患者36例,阳性率为65.45%,治疗6个月后血清抗PLA2R抗体阳性患者25例,阳性率45.45%。且治疗前血清抗PLA2R抗体滴度与尿蛋白定量呈正相关,与血清白蛋白、总蛋白呈负相关;治疗6个月后血清抗PLA2R抗体滴度与尿蛋白定量呈正相关,与血清白蛋白、总蛋白呈负相关。结论血清抗PLA2R抗体可作为IMN血清学诊断的指标之一,血清抗PLA2R抗体滴度下降与尿蛋白的减少密切相关,与疾病预后、病情转归也可能相关。
[Abstract]:Objective to study the correlation between the positive titer of serum anti-M phospholipase A2 receptor PLA2R and other laboratory indexes in adult idiopathic membranous nephropathy (IMN). To investigate the role of anti PLA2R antibody in the diagnosis and evaluation of IMN. Methods 55 patients with IMN confirmed by renal biopsy guided by B-ultrasound were followed up for 6 months and 15 healthy persons were selected as control group. Elisa was used to detect serum anti PLA2R antibody, and 24 h urine protein, serum total protein, serum albumin, serum total cholesterol and serum creatinine were detected in patients with IMN. The serum anti PLA2R antibody was lower than that before treatment in 47 cases (85.45%) of serum anti PLA2R antibody positive in 55 cases of IMN before treatment, and 36 cases of anti PLA2R antibody positive in serum after 3 months of treatment. The positive rate was 65.45, and the positive rate was 45.45 in 25 patients with anti PLA2R antibody after 6 months of treatment. The titer of anti PLA2R antibody was positively correlated with urinary protein before treatment, and negatively correlated with serum albumin and total protein. After 6 months of treatment, the titer of serum anti PLA2R antibody was positively correlated with urine protein, and negatively correlated with serum albumin and total protein. Conclusion Serum anti PLA2R antibody can be used as one of the indexes of IMN serological diagnosis. The decrease of serum anti PLA2R antibody titer is closely related to the decrease of urinary protein, and may also be related to the prognosis and prognosis of the disease.
【作者单位】：潍坊医学院;山东省潍坊市人民医院;
【分类号】：R692

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