最大尿流率变化值检测在判断尿道狭窄中的应用价值

发布时间：2018-03-21 15:57

本文选题：尿道狭窄　切入点：最大尿流率变化值　出处：《苏州大学》2014年硕士论文　论文类型：学位论文

【摘要】：1目的在尿道成形术术后，一种值得信赖的，对患者无创的筛查尿道再狭窄的方法是迫切需要的。我们推测术后尿流率与术前相比较（最大尿流率变化值），有可能帮助预测术后尿道狭窄复发。 2方法回顾性分析了本院从2012年3月到2013年11月间279名经历尿道重建手术男性患者资料。187名患者在术前和术后都对尿流率做了充分研究,并且所有患者行尿道造影金标准检查，判别尿道狭窄情况。根据术后最大尿流率改变截点值绘制ROC曲线，分析最大尿流率变化值判别尿道狭窄方法的准确性。 3结果在这个研究里，包含了总共279名男性患者接受尿道成形术，其中187名患者在术前和术后进行了充分的尿流率检测，尿道造影检查研究。术前患者最大尿流率的平均值是11.2±0.8ml/s。131名无狭窄患者最大尿流率是18.6±11.3ml/s，与术前有显著性统计学差异（p0.0001）。而56名狭窄患者最大尿流率是10.6±7.2ml/s,与术前无统计学差异（p=0.2630）。成功修复尿道的病人，，最大最大尿流率变化值平均值为19.2±11.7ml/s，对于不成功的修复尿道病人，最大最大尿流率变化值平均值为2.7±8.4ml/s,两者相比,具有显著性差异（p0.0001）。利用187名病人最大尿流率变化值的截点值绘制的ROC曲线显示。作为尿道狭窄患者复发的筛选标准，当最大尿流率变化值等于10ml/s时，能分别形成了92％灵敏度和78％的特异度。 4结论对于尿道狭窄病人，最大尿流率变化值检测是一种有前途的筛查尿道再狭窄的方法，它具有无创性和高度敏感性。在尿道狭窄术后诊断再狭窄具有很高的应用价值。
[Abstract]:Objective to provide a reliable method for urethroplasty. A noninvasive method for screening urethral restenosis is urgently needed. We speculate that the postoperative urinary flow rate is compared with that before operation (the maximum flow rate change value may help to predict the recurrence of postoperative urethral stricture.). Methods the data of 279 male patients undergoing urethral reconstruction from March 2012 to November 2013 were analyzed retrospectively. The ROC curve was drawn according to the change point of the maximum flow rate after operation, and the accuracy of the method of judging urethral stricture was analyzed by analyzing the change value of the maximum flow rate of urethra. Results in this study, a total of 279 male patients underwent urethroplasty, 187 of whom underwent adequate urine flow tests before and after surgery. Study on urethrography. The mean maximum flow rate was 11.2 卤0.8 ml / s. 131 patients without stenosis, which was 18.6 卤11.3 ml / s, which was significantly different from that before operation (p 0.0001), while the maximum flow rate in 56 patients with stenosis was 10.6 卤7.2 ml / s, which was not statistically significant compared with that before operation. Patients with successful urethral repair, The mean value of the maximum flow rate was 19.2 卤11.7ml / s, and for the unsuccessful urethral repair patients, the mean value of the maximum flow rate was 2.7 卤8.4 ml / s. There was significant difference between the two groups (p 0.0001). The ROC curve was drawn using the cut-off point of the maximum uroflow rate change value in 187 patients. As a screening criterion for recurrence in urethral stricture patients, when the maximum uroflow rate change value was equal to 10 ml / s, The sensitivity of 92% and the specificity of 78% were obtained. Conclusion for urethral stricture patients, the detection of maximum flow rate is a promising screening method for urethral restenosis, which is noninvasive and highly sensitive, and has a high value in the diagnosis of restenosis after urethral stricture.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R695

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