糖肾方联合贝前列素钠影响糖尿病肾病患者炎症因子及安全性的临床观察

发布时间：2018-03-22 00:15

本文选题：糖肾方　切入点：贝前列素钠　出处：《中国实验方剂学杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的:观察糖肾方联合贝前列素钠对糖尿病肾病患者(DKD)炎症因子的影响及安全性。方法:单纯应用糖肾方(中药组)、贝前列素钠(西药组)与两者联合应用(合用组)进行随机平行对照研究,观察各组患者给药前后临床疗效、中医证候积分、空腹血糖(FBG)、尿蛋白排泄率(UAER)及相关炎性细胞因子转化生长因子(TGF)-β1,肿瘤坏死因子(TNF)-α及白细胞介素(IL)-18等的变化。结果:与治疗前比较,各组治疗后各项指标均降低;与西药组比较,中药组患者FBG水平明显降低(P0.05);与中药组比较,西药组患者IL-18水平明显降低(P0.05);与中药组、西药组比较,合用组患者临床总有效率升高(P0.05),合用组患者的肾气虚相关症状(腰膝酸软、口干不欲饮)积分,FBG水平,UAER水平以及炎症因子水平均明显降低(P0.05);与西药组比较,合用组患者脾气虚相关症状(纳差乏力、肢体浮肿)积分明显降低(P0.05)。3组患者研究过程中均未发现严重不良反应。结论:糖肾方与贝前列素钠联用,可提高降低患者尿蛋白,改善炎症状态的作用,对临床期DKD有较好的治疗效果。
[Abstract]:Objective: to observe the effect and safety of Tangshen recipe combined with beprost sodium on inflammatory factors of diabetic nephropathy patients with DKD. Methods: Tangshen recipe (traditional Chinese medicine group), beprostol sodium (western medicine group) and combined therapy (combined with both) were used. In a randomized, parallel controlled study, Observe the clinical effect before and after administration of drugs, TCM syndrome score, The changes of FBGG, urinary protein excretion rate (UAER-UAER), TGF- 尾 _ 1, TNF- 伪 and IL-IL-18, and so on. Results: compared with those before and after treatment, the indexes of each group were decreased, and those of western medicine group were lower than those of western medicine group, and the changes of TGF- 尾 1, TNF- 伪 and IL-IL-18 in each group were lower than those before treatment, and compared with those in western medicine group. Compared with the traditional Chinese medicine group and the western medicine group, the level of IL-18 in the western medicine group was significantly lower than that in the traditional Chinese medicine group and the western medicine group. Compared with the traditional Chinese medicine group and the western medicine group, the total clinical effective rate of the combined group was higher than that of the traditional Chinese medicine group and the western medicine group. The FBG level, UAER level and inflammatory factor level were significantly lower than those in the western medicine group, and compared with the western medicine group, the symptoms related to spleen qi deficiency (anorexia) in the combined group were significantly lower than those in the western medicine group. Conclusion: the combination of Tangshen recipe and beprostol sodium can improve the effect of reducing urine protein and improving inflammatory state in patients with lower urinary protein and lower inflammatory state, and no serious adverse reactions were found in the study of P0.050.Conclusion: the combination of Tangshen recipe and beprostol sodium can increase the level of urinary protein and improve the inflammatory state of the patients. It has good therapeutic effect on DKD in clinical stage.
【作者单位】：上海中医药大学附属第七人民医院;
【基金】：上海市卫生和计划生育委员会中医药科研基金项目(2014LP032A);上海市卫生和计划生育委员会科研计划项目(201440543) 上海市科学技术委员会科研计划项目(15401930600)
【分类号】：R587.2;R692.9

【相似文献】