癌症患者生命质量测定量表体系之前列腺癌量表QLICP-PR的研制与评价

发布时间：2018-03-22 09:34

本文选题：生命质量　切入点：前列腺癌　出处：《昆明医科大学》2016年硕士论文　论文类型：学位论文

【摘要】：[目的]研制癌症患者生命质量测定量表体系之前列腺癌量表(The Quality of Life Instrument for Cancer Patients-prostate cancer, QLICP-PR)以及欧洲癌症研究和治疗组织的EORTC QLQ-PR55 (Quality of Life Questionnaire: EORTC QLQ-C30; QLQ-PR25)中文版量表,分别考评并比较两个量表。[方法]依据共性模块与特异模块相结合的研究思想,通过大量回顾国内外相关文献资料,结合国内文化特点,以开发量表的程序化决策方式研制QLICP-PR量表,主要包括：访谈、小组集中讨论、统计分析结合临床实际等。同时通过量表汉化的一系列包括翻译、回译、文化调试等步骤研制QLQ-PR25中文版,再同已有的QLQ-C30中文版结合形成QLQ-PR55中文版量表。采用两个量表在入院时对115例前列腺癌患者进行第一次测试,其中,94例患者于入院2-3天进行第二次量表测试；99例患者于出院时进行第三次量表测试,通过最终的调查数据来考评两个量表的测量学特性(信度、效度、反应度),同时对两个量表进行比较。在处理数据分析时采用的统计学方法有：统计描述、配对t检验、相关性分析、探索性因子分析等。[结果]1.研制出了含21个条目的前列腺癌特异模块,与已有含32个条目的共性模块QLICP-GM结合形成前列腺癌患者生命质量量表QLICP-PR;同时,还研制出了EORTC QLQ-PR55中文版量表。2.对QLICP-PR量表进行考评,结果显示该量表的重测信度为0.920,克朗巴赫系数为0.884,分半信度为0.837;概化理论研究结果显示心理功能领域(9条)、社会功能领域(8条)、共性症状和副作用领域(7条)、特异模块(21条)设置条目数适宜,而躯体功能领域(8条)应适当增加条目。相关分析和因子分析显示QLICP-PR量表的结构效度尚可,采用QLQ-PR55中文版量表作为效标分析可知,QLICP-PR量表具有较好的效标效度。除性功能问题外,其余领域治疗前后得分的配对t检验均有统计学意义(P0.05),该量表基本能反映出患者治疗前后生命质量的变化情况。3.对QLQ-PR55中文版量表进行考评,并将QLICP-PR量表与QLQ-PR55中文版量表进行比较：从内容上看,两量表均能反映生命质量测量的基本内容,但存在异同点；从测量学特性上看,两量表的信度、反应度均较好,效度尚可,其中信度、结构效度、反应度接近,且均具有较好的内容效度。[结论]前列腺癌患者生命质量量表QLICP-PR有较好的信度、反应度,效度尚可,可用于中国前列腺癌患者生命质量的测评。QLICP-PR量表与QLQ-PR55中文版量表比较,内容上存在异同点；测量学特征上两量表类似。
[Abstract]:[objective] to develop the Quality of Life Instrument for Cancer Patients-prostate cancer (QLICP-PRA) and EORTC QLQ-PR55 quality of Life questionnaire naive: EORTC QLQ-C30; QLQ-PR25 of the European Organization for Research and treatment of Cancer. [methods] according to the research thought of the combination of common module and specific module, through reviewing a large number of domestic and foreign relevant literature materials, combined with the characteristics of domestic culture, The QLICP-PR scale is developed by developing the program decision of the scale, including interview, group discussion, statistical analysis combined with clinical practice, etc. At the same time, a series of Chinese version of the scale includes translation, backtranslation, etc. The Chinese version of QLQ-PR25 was developed and combined with the existing Chinese version of QLQ-C30 to form the Chinese version of QLQ-PR55. Two scales were used to test 115 patients with prostate cancer for the first time on admission. Among them, 94 patients were tested by the second scale on 2-3 days after admission. 99 patients were tested with the third scale when they were discharged from hospital. The measuring characteristics (reliability, validity) of the two scales were evaluated by the final survey data. The statistical methods used in processing data analysis are: statistical description, paired t test, correlation analysis. Exploratory factor analysis and so on. [results] 1. A 21 item prostate cancer specific module was developed, which was combined with QLICP-GM, a common module with 32 items, to form QLICP-PR1. The Chinese version of EORTC QLQ-PR55 is also developed. 2. The QLICP-PR scale is evaluated. The results showed that the test-retest reliability of the scale was 0.920, the Cronbach coefficient was 0.884, and the split-half reliability was 0.837. The results of the generalization theory showed that there were 9 cases in psychological function, 8 in social function, 7 in common symptoms and side effects. The number of items set is appropriate, Correlation analysis and factor analysis showed that the structure validity of QLICP-PR scale was fairly good. The Chinese version of QLQ-PR55 scale was used to analyze the validity of QLICP-PR. Except for sexual function problems, QLICP-PR scale had good validity. The paired t test of scores in other fields before and after treatment had statistical significance (P 0.05). The scale could basically reflect the changes of quality of life of patients before and after treatment. 3. The Chinese version of QLQ-PR55 was evaluated. Comparing the QLICP-PR scale with the Chinese version of QLQ-PR55, the two scales can reflect the basic content of the quality of life measurement, but there are similarities and differences, from the measurement characteristics, the reliability and response of the two scales are good, and the validity is good. Among them, reliability, structure validity, response degree were close, and all had good content validity. [conclusion] QLICP-PR has good reliability, response and validity in prostate cancer patients. The QLICP-PR scale can be used to evaluate the quality of life of prostate cancer patients in China. Compared with the Chinese version of QLQ-PR55, there are similarities and differences in the content of QLICP-PR and the two scales are similar in measuring characteristics.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R737.25

【相似文献】