2型糖尿病患者踝臂指数与尿微量白蛋白肌酐比相关性的研究

发布时间：2018-03-23 21:49

本文选题：2型糖尿病　切入点：踝臂指数(ABI)　出处：《广西医科大学》2014年硕士论文

【摘要】：目的：探讨2型糖尿病患者踝臂指数（ABI）与尿微量白蛋白肌酐比（ACR）的相关性，，为防治糖尿病肾病提供新的临床依据。方法：共收集310例2型糖尿病患者，依据ABI测定结果分为ABI下降组（75例）及ABI正常组（235例），比较两组病人间ACR指标的差异，进一步将ABI下降组的病人分为轻度下降组和中度下降组，比较两组间ACR的差异，分析ABI与ACR的相关性。结果：ABI下降组ACR异常率明显高于ABI正常组，分别为68.00%、6.38%，组间差异有统计学意义（P0.05），两组的年龄、病程、收缩压、舒张压、体重指数、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯水平、白细胞计数、糖化血红蛋白间差异均无统计学意义（P0.05），ABI中度下降组ACR异常率高于ABI轻度下降组，分别为84.00%、60%，组间差异有统计学意义（P0.05），相关分析提示ABI与ACR呈负相关（r=-0.412，P0.01）。结论：ABI下降组ACR异常率较ABI正常组明显升高，相关分析提示ABI与ACR显著相关，提示ABI的变化可能是糖尿病肾病的独立危险因素。
[Abstract]:Objective: to investigate the correlation between ABI and urinary albumin creatinine ratio (ACRR) in type 2 diabetic patients, and to provide a new clinical basis for the prevention and treatment of diabetic nephropathy. Methods: a total of 310 patients with type 2 diabetes mellitus were divided into two groups according to the results of ABI measurement: 75 patients with decreased ABI and 235 patients with normal ABI. The difference of ACR indexes between the two groups was compared. The patients with decreased ABI were further divided into mild group and moderate group. The difference of ACR between the two groups was compared and the correlation between ABI and ACR was analyzed. Results the abnormal rate of ACR in the decreased group of ABI was significantly higher than that in the normal group (68.00 卤6.38, P 0.05). The age, course of disease, systolic blood pressure, diastolic blood pressure, body mass index, total cholesterol, high density lipoprotein cholesterol in the two groups were significantly higher than those in the control group. There was no significant difference in low density lipoprotein cholesterol, triglyceride level, white blood cell count and glycosylated hemoglobin between the two groups. The abnormal rate of ACR in the moderate decrease group was higher than that in the mild ABI group. The difference between the two groups was statistically significant (P 0.05). The correlation analysis indicated that ABI and ACR were negatively correlated with ACR. Conclusion the abnormal rate of ACR in the descending group of ABI is significantly higher than that in the normal group of ABI. The correlation analysis indicates that ABI is significantly correlated with ACR, suggesting that the change of ABI may be an independent risk factor for diabetic nephropathy.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R587.2;R692

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