海昆肾喜胶囊治疗慢性肾功能衰竭的Meta分析

发布时间：2018-03-24 22:23

本文选题：海昆肾喜胶囊　切入点：慢性肾功能衰竭　出处：《中国药房》2017年27期

【摘要】：目的:系统评价海昆肾喜胶囊治疗慢性肾功能衰竭(CRF)的疗效,为临床提供循证参考。方法:计算机检索Central、Pub Med、EMBase、相关期刊论文(CJFD)、中国生物医学文献数据库(CBM)、中文科技期刊数据库(VIP)和万方数据库,收集海昆肾喜胶囊联合常规方案(试验组)对比单纯常规方案(对照组)治疗CRF的随机对照试验(RCT),筛选文献、提取资料并采用Cochrane协作网提供的风险偏倚评估图评价质量后,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入10项RCT,合计704例患者。Meta分析结果显示,试验组患者总有效率显著高于对照组[RR=4.42,95%CI(2.70,7.22),P0.001],血肌酐[MD=-140.37,95%CI(-191.72,-89.03),P0.001]、血尿素氮[MD=-5.49,95%CI(-8.36,-2.63),P0.001]和24 h尿蛋白定量[MD=-0.43,95%CI(-0.62,-0.23),P0.001]均显著低于对照组,差异均有统计学意义。结论:海昆肾喜胶囊治疗CRF疗效较好,可以显著改善患者相关肾功能指标。
[Abstract]:Objective: to evaluate the efficacy of Haikunshenxi capsule in the treatment of chronic renal failure (CRF). Methods: Evidence-based reference was provided for clinic. Methods: central Pub Meden EMBase, China Journal Full-text Database (CJFDN), Chinese Biomedical Literature Database (CBMN), Chinese Sci-tech Journal Database (VIP) and Wanfang Database were searched by computer. A randomized controlled trial (RCTT) of the combination of Haikunshenxi capsule and conventional regimen (trial group) was collected for the treatment of CRF compared with the control group. The literature was screened, the data was extracted and the risk bias assessment map provided by the Cochrane cooperative network was used to evaluate the quality. Meta analysis was carried out with Rev Man 5.3 software. Results: a total of 10 items of Meta were included, and a total of 704 patients. Meta-analysis results showed that, The total effective rate of the patients in the trial group was significantly higher than that in the control group [RRN 4.42J 95 CII 2.70 7.22 P0.001], the serum creatinine [MD-140.3795 + CI-191.72 -89.03 P0.001], the blood urea nitrogen [MD-5.495CI-8.36-2.63C P0.001] and the 24 h urine protein quantity [MD-0.4395CI-0.62- 0.23P0.001] were significantly lower than those in the control group. Conclusion: the therapeutic effect of Haikun Shenxi capsule on CRF is better than that of the control group. It can significantly improve the renal function of patients.
【作者单位】：广东省中医院;广州中医药大学第二临床医学院;广州中医药大学第二附属医院;
【基金】：国家科技支撑计划课题(No.2013BAI02B04) 广东省中医院中医药科学技术研究专项项目(No.2014KT1305)
【分类号】：R692.5

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