PTGES2在LPS所致急性肾损伤中对p62的抑制作用研究

发布时间：2018-03-28 18:31

本文选题：小鼠肾组织　切入点：急性肾损伤　出处：《中国病理生理杂志》2015年10期

【摘要】：正目前,PTGES2在脓毒症中的作用尚不清楚。本研究首次发现在LPS刺激后C57BL/6小鼠肾组织中PTGES2的表达较正常对照组明显增高。采用免疫组织化学方法检测发现,PTGES2主要定位于近曲小管上皮细胞的细胞浆中,在肾小球和肾髓质未见明显表达。为了探讨PTGES2与自噬的关系,本研究对LPS刺激时小鼠肾组织中自噬接头蛋白p62的表达进行检测,结果发现在LPS刺激后C57BL/6小鼠肾组织中p62的表达较正常对照组明显降低,与PTGES2的表达呈负相关关系;采用免
[Abstract]:At present, the role of PTGES2 in sepsis is not clear. This study first found that the expression of PTGES2 in renal tissue of C57BL/6 mice after LPS stimulation was significantly higher than that of normal control group. The main localization of PTGES2 was detected by immunohistochemical method. In the cytoplasm of the epithelial cells of the proximal convoluted tubules, In order to investigate the relationship between PTGES2 and autophagy, the expression of autophagy junction protein p62 in renal tissue of mice stimulated by LPS was detected. The results showed that the expression of p62 in renal tissue of C57BL/6 mice after LPS stimulation was significantly lower than that of normal control group, and negatively correlated with the expression of PTGES2.
【作者单位】：中南大学湘雅医学院病理生理学系;
【分类号】：R459.7;R692

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