M型磷脂酶A2受体相关检测在成人特发性膜性肾病诊断中的应用

发布时间：2018-03-30 21:42

本文选题：特发性膜性肾病　切入点：磷脂酶A受体　出处：《中国现代医学杂志》2017年05期

【摘要】：目的探讨血清抗M型磷脂酶A2受体(PLA2R)抗体和肾小球PLA2R联合检测在成人特发性膜性肾病诊断中的应用。方法回顾性分析2015年1月-2016年1月就诊于郑州大学第一附属医院肾内科经肾穿刺活检术诊断为特发性膜性肾病(IMN)患者205例和非IMN患者89例的临床及实验室资料,包括血清抗PLA2R抗体和肾小球PLA2R检测结果。结果IMN组血清抗PLA2R抗体阳性率为68.3%(140/205),肾小球PLA2R阳性率为71.7%(147/205),其中两者共阳性者52.2%(107/205),两者共阴性者12.2%(25/205),血清抗PLA2R抗体阳性而肾小球PLA2R阴性者16.1%(33/205),血清抗PLA2R抗体阴性而肾小球PLA2R阳性者19.5%(40/205)。血清抗PLA2R抗体诊断IMN的敏感性为68.3%,特异性为96.6%,受试者工作特征(ROC)曲线下面积为0.859;肾小球PLA2R诊断IMN的敏感性为71.7%,特异性为83.1%,ROC曲线下面积为0.777,两者联合检测的ROC曲线下面积为0.878。结论血清抗PLA2R抗体和肾小球PLA2R是诊断IMN既敏感又特异的指标,两者联合检测更有助于IMN的诊断。
[Abstract]:Objective to investigate the application of serum anti-type phospholipase A 2 receptor (PLA2R) antibody and glomerular PLA2R in the diagnosis of adult idiopathic membranous nephropathy (IDN). Methods A retrospective analysis was conducted from January 2015 to January 2016 at Zhengzhou University. Clinical and laboratory data of 205 patients with idiopathic membranous nephropathy (IMN) and 89 patients without IMN diagnosed by renal biopsy in affiliated hospital. Results the positive rate of anti PLA2R antibody and glomerular PLA2R in IMN group was 68.3%, and the positive rate of glomerular PLA2R was 71. 777 / 205%, 52.2% 107 / 205%, 12. 22525 / 205% and 12. 22525 / 205%, respectively, and the positive rate of anti PLA2R antibody was 71.77 / 205% in IMN group, and the positive rate of anti PLA2R antibody in glomeruli was 12. 22525 / 205%, while that of glomeruli in IMN group was 12. 22525 / 205%, and the positive rate of glomerular PLA2R was 71. 777 / 205%. The sensitivity of serum anti-#en3# antibody was 68.3% and specificity was 96.6%. The area under the curve of PLA2R was 0.859, and the sensitivity of glomerular PLA2R to IMN diagnosis was 71.7%, the sensitivity of glomerular PLA2R was 71.7%, the sensitivity of glomerular PLA2R was 71.7%, the sensitivity of glomerular PLA2R was 71.7% (P < 0.05), the sensitivity of serum anti-#en3# antibody was 68.3%, the specificity was 96.6%, and the area under the curve of PLA2R was 0.859, and the sensitivity of glomerular PLA2R was 71.7%. The specific area under the ROC curve was 0.777, and the area under the ROC curve was 0.878. Conclusion Serum anti PLA2R antibody and glomerular PLA2R are sensitive and specific indexes for the diagnosis of IMN. Combined detection is more helpful for the diagnosis of IMN.
【作者单位】：郑州大学第一附属医院肾脏病中心;郑州大学第一附属医院肾病实验室;
【分类号】：R692.3

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