西宁地区血清中性粒细胞与淋巴细胞比值与早期糖尿病肾病的相关性研究

发布时间：2018-03-31 15:58

本文选题：中性粒细胞与淋巴细胞比值　切入点：炎症　出处：《青海大学》2017年硕士论文

【摘要】：目的:近年来国内外不少学者均报道血清中性粒细胞与淋巴细胞比值(NLR)可较早有效地警示糖尿病及其慢性微血管并发症的产生,本课题将进一步探讨西宁地区NLR与早期糖尿病慢性肾病变的相关性。方法:对随机抽取的320例研究对象分为早期糖尿病肾病组(DN组)、单纯2型糖尿病组(T2DM组)及对照组,主要分析比较NLR水平在3组间的变化。结果:1、单因素方差分析显示:三组间BMI、TCH、LDL、Cr、MC、FINS差异无统计学意义(P0.05);DN组在年龄、病程、NLR、WBC、NC、Hb A1c、FPG、2h PG、IR、Cys C均显著高于T2DM组,且T2DM组在以上指标也都同时高于对照组,差异具有统计学意义(P0.05);DN组腰围、BUN高于T2DM组和对照组,LC、HDL低于糖尿病组和对照组,且在后两组间差异无统计学意义(P0.05);DN组和T2DM组TG(X2=9.179和X2=17.325,均P0.05)、hs-CRP(X2=921.606和X2=8.864,均P0.05)高于对照组。2、二分类多因素Logistic回归分析显示:年龄、病程、Hb A1c、IR、NLR是早期糖尿病肾病的主要危险因素,其中NLR具有更大的危险系数(OR=28.609)。3、Pearson或Spearman相关分析显示:年龄、病程、Hb A1c、IR、NLR与尿微量白蛋白呈正相关,其中NLR具有更大的相关系数(r=0.558)。结论:1、在西宁地区年龄、WBC、NC、NLR、Hb A1c、IR、Cys C随着2型糖尿病的进展逐渐升高,而糖尿病肾病患者体内LC降低,可能是机体慢性炎症状态与免疫系统异常的双重结果。2、年龄、病程、Hb A1c、IR、NLR与尿微量白蛋白呈正相关,是早期糖尿病肾病的主要危险因素,其中NLR具有更大的相关系数和危险系数,可预测早期糖尿病肾病的发生。
[Abstract]:Objective: in recent years, many scholars at home and abroad have reported that the ratio of serum neutrophils to lymphocytes (NLRR) can warn the occurrence of diabetes mellitus and its chronic microvascular complications early and effectively. This study will further explore the relationship between NLR and early diabetic chronic nephropathy in Xining area. Methods: 320 patients were randomly divided into two groups: early diabetic nephropathy group (DN group), type 2 diabetic group (T2DM group) and control group. Results: there was no significant difference among the three groups in the changes of NLR level among the three groups. Results: there was no significant difference among the three groups in terms of age and course of disease (P 0.05). The age and course of disease were significantly higher than those of T2DM group at 2 h. All the above indexes in T2DM group were also higher than those in control group, and the difference was statistically significant. The waist circumference bun in T2DM group was higher than that in T2DM group and control group, which was lower than that in diabetic group and control group. There was no significant difference between the latter two groups in TG(X2=9.179 and X2O17.325, both P0.05hs-CRPHX 921.606 and X2C8.864) were significantly higher than those in control group (P 0.05). Logistic regression analysis showed that age, course of disease, HB A1C / IRNLR were the main risk factors for early diabetic nephropathy. Among them, NLR had a higher risk coefficient (P < 0.05). Pearson or Spearman correlation analysis showed that there was a positive correlation between age, course of disease and urinary microalbuminuria. The correlation coefficient of NLR was 0.5580.Conclusion in Xining area, the age of WBCX, NLRRN, Hb, A1C and IRCys C gradually increased with the development of type 2 diabetes, but the LC in patients with diabetic nephropathy was lower than that in patients with diabetic nephropathy. It may be a double result of chronic inflammation and abnormal immune system. Age, course of disease, HbA1cIRNLR is positively correlated with urinary microalbumin, and it is the main risk factor of early diabetic nephropathy, in which NLR has higher correlation coefficient and risk coefficient. Early diabetic nephropathy can be predicted.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.2;R692.9

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