不同激素量联合环磷酰胺及雷公藤治疗中老年肾病综合征的疗效

发布时间：2018-04-02 12:01

本文选题：激素　切入点：环磷酰胺　出处：《中国老年学杂志》2017年01期

【摘要】：目的探讨不同激素量联合环磷酰胺及雷公藤在治疗中老年肾病综合征时的不同效果。方法选取中老年肾病综合征患者80例,随机分为四组,每组20例。在环磷酰胺和雷公藤用药的基础上,各组分别给予不同剂量的醋酸泼尼松,在第1,3,6和12个月监测患者的尿蛋白定量,血浆白蛋白及血肌酐含量,判定其症状缓解率及复发率。此外,在治疗后的各时段,观察各组患者不良反应的发生。结果激素联合环磷酰胺及雷公藤用于治疗中老年肾病综合征产生了良好的效果,在醋酸泼尼松用量为1.0 mg·kg~(-1)·d~(-1),临床效果最好(P0.05),且复发率及不良反应发生率与其他组无明显差异(P0.05)。结论 1.0 mg·kg~(-1)·d~(-1)用量的醋酸泼尼松联合环磷酰胺及雷公藤治疗成人难治性肾病综合征具有较高的临床缓解率,显著改善了肾功能指标。
[Abstract]:Objective to investigate the different effects of different hormone doses combined with cyclophosphamide and tripterygium wilfordii in the treatment of nephrotic syndrome in middle-aged and elderly patients. Methods 80 middle-aged and aged patients with nephrotic syndrome were randomly divided into four groups. On the basis of cyclophosphamide and tripterygium wilfordii, each group was given different doses of prednisone acetate. The urinary protein, plasma albumin and serum creatinine were measured at the 6th and 12th month after treatment. In addition, adverse reactions were observed in each period of time after treatment. Results hormone combined with cyclophosphamide and Tripterygium wilfordii showed good effect in the treatment of middle-aged and old patients with nephrotic syndrome. When the dosage of prednisone acetate was 1.0 mg / kg ~ (-1) d ~ (-1), the clinical effect was better than that of P0.05, and the recurrence rate and the incidence of adverse reactions were not significantly different from those of other groups. Conclusion the dosage of prednisone acetate combined with cyclophosphamide and Tripterygium wilfordii for the treatment of refractory adult patients is not significantly different from that of other groups (1.0 mg 路kg ~ (-1)) of prednisone acetate and cyclophosphamide and tripterygium wilfordii. Nephrotic syndrome has high clinical remission rate. The renal function index was improved significantly.
【作者单位】：桂林医学院附属医院肾内科;
【基金】：广西壮族自治区卫生厅自筹经费科研课题(Z2012423)
【分类号】：R692

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