复方α-酮酸片治疗2型糖尿病合并早期糖尿病肾病的临床观察

发布时间：2018-04-03 17:22

本文选题：复方α-酮酸片　切入点：型糖尿病　出处：《中国药房》2017年35期

【摘要】：目的:观察复方α-酮酸片治疗2型糖尿病(T2DM)合并早期糖尿病肾病(DN)的临床疗效及安全性。方法:选取2013年1月-2015年12月我院收治的T2DM合并早期DN患者180例作为研究对象,采用随机数字表法分为A、B、C组,各60例。C组患者给予基础对症治疗;A组患者在C组基础上口服复方α-酮酸片2.52 g,tid;B组患者在C组基础上口服复方α-酮酸片5.04 g,tid。3组患者均连续治疗24周。观察3组患者治疗前后的肾功能指标[血尿素氮(BUN)、血肌酐(Cr)、肾小球滤过率(GFR)、尿白蛋白量(尿ALB)]、血糖指标[空腹血糖(FPG)、餐后2 h血糖(PPG)、糖化血红蛋白(Hb A1c)]、血压指标[收缩压(SBP)、舒张压(DBP)]、营养指标[血清白蛋白(ALB)、前白蛋白(PA)、血红蛋白(Hb)],并记录3组患者不良反应发生情况。结果:治疗前,3组患者肾功能指标、血糖指标、血压指标、营养指标比较,差异均无统计学意义(P0.05)。治疗后,3组患者的尿ALB、HbA_1c、SBP水平均显著下降,且B组显著低于A组,A组显著低于C组;A、C组患者的ALB、PA、Hb水平均显著下降,且B组显著高于A组,A组显著高于C组,差异均有统计学意义(P0.05)。3组患者的不良反应发生率分别为8.3%、10.0%和6.7%,差异无统计学意义(P0.05)。结论:复方α-酮酸片能显著改善T2DM合并早期DN患者的肾功能,有效控制血糖、血压水平并补充必需营养物质,且具有较高的安全性,较大剂量效果更优。
[Abstract]:Objective: to observe the clinical efficacy and safety of compound 伪 -ketoacid tablets in the treatment of type 2 diabetes mellitus (T2DM) combined with early diabetic nephropathy (DN).Methods: from January 2013 to December 2015, 180 patients with T2DM complicated with early DN were selected as study objects.The indexes of renal function before and after treatment [blood urea nitrogen bun, serum creatinine creatinine, glomerular filtration rate (GFRN), urinary albumin (ALBN)], fasting blood glucose (FBG), postprandial blood glucose (PPG), glycosylated hemoglobin (HbA1c), blood pressure were observed.[SBP, DBP], nutritional index [Albumin, PAA, HB], and the adverse reactions in three groups were recorded.Results: there was no significant difference in renal function index, blood glucose index, blood pressure index and nutrition index between the three groups before treatment (P 0.05).The incidence of adverse reactions in P0.05.3 group was 10.0% and 6.7%, respectively. The difference was not statistically significant (P 0.05).Conclusion: compound 伪 -ketoacid tablets can significantly improve the renal function of T2DM patients with early DN, effectively control blood glucose, blood pressure and supplement essential nutrients, and have higher safety and higher dose effect.
【作者单位】：昆明医科大学第二附属医院药学部;
【分类号】：R587.2;R692.9

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