Ki-67在T1期非肌层浸润性膀胱癌中的表达及意义

发布时间：2018-04-11 05:22

  本文选题：T期非肌层浸润性膀胱癌 + Ki-表达　； 参考：《中国肿瘤临床》2017年07期

【摘要】：目的:检测Ki-67在T1期非肌层浸润性膀胱癌(non-muscle invasive bladder cancer,NMIBC)组织中的表达,并探讨其与肿瘤复发和进展的关系。方法:回顾性分析2011年6月至2013年10月天津医科大学肿瘤医院102例T1期NMIBC患者的临床病理资料,利用免疫组织化学方法检测组织中Ki-67的表达,分析Ki-67表达与患者临床病理特征的关系,探讨其对T1期NMIBC复发和进展的影响。结果:中位随访时间43(24~57)个月,102例T1期NMIBC患者中20例(19.6%)复发,12例(11.8%)进展,32例(31.4%)Ki-67表达≥25%。Ki-67表达与肿瘤分级相关(P0.05),与患者性别、年龄、肿瘤数目、肿瘤大小等无相关性(P0.05)。单因素分析结果显示,Ki-67表达与T1期NMIBC的复发无相关性(P0.05),Ki-67表达、肿瘤分级、肿瘤数目和既往复发率是影响T1期NMIBC进展的危险因素(P0.05),Cox风险回归模型多因素分析结果显示,Ki-67高表达(P=0.043)和既往复发率(P=0.018)是影响T1期NMIBC进展的独立危险因素。结论:Ki-67表达是T1期NMIBC的独立预后因素,检测Ki-67表达有助于预测其进展风险,为采取及时有效治疗提供依据。
[Abstract]:Objective: to detect the expression of Ki-67 in non-muscle invasive bladder cancer of T 1 stage of bladder cancer, and to investigate the relationship between the expression of Ki-67 and tumor recurrence and progression.Methods: the clinicopathological data of 102 patients with T1 stage NMIBC in Tianjin Medical University Oncology Hospital from June 2011 to October 2013 were retrospectively analyzed. The expression of Ki-67 was detected by immunohistochemistry.To analyze the relationship between the expression of Ki-67 and the clinicopathological features of the patients, and to explore its influence on the recurrence and progression of T 1 NMIBC.Results: the median follow-up time was 43 / 24 / 57) in 102 patients with T1 stage NMIBC (20 / 102) with recurrence and recurrence (12 / 11.8)). The expression of Ki-67 鈮，

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