尿酸肾损伤的研究进展

发布时间：2018-04-11 19:43

本文选题：尿酸盐结晶 + 慢性尿酸盐肾病　；参考：《上海医学》2017年01期

【摘要】：正尿酸肾损伤是包括急性尿酸肾病(UAN)、慢性尿酸盐肾病~([1])和尿酸肾结石~([2])在内的一组疾病,三者可互相重叠。既往有学者将慢性尿酸盐肾病称为"痛风肾病",但由于痛风指高尿酸血症的关节损伤,与慢性尿酸盐肾病同属高尿酸血症的并发症,故不推荐使用痛风肾病的名称。尿酸肾损伤主要由尿酸和尿酸盐结晶在肾脏沉积而引起的氧化应激、炎性反应等所致。短时间尿尿酸水平急剧升高可导致UAN,而长期尿尿酸水平升
[Abstract]:Positive uric acid renal injury is a group of diseases including acute uric acid nephropathy, chronic uric acid nephropathy ([1]) and uric acid nephrolithiasis ([2]), which can overlap each other.Some scholars have called chronic uric acid nephropathy "gout nephropathy", but because of the joint injury of hyperuricemia and the complication of hyperuricemia with chronic uric acid nephropathy, it is not recommended to use the name of gout nephropathy.Uric acid renal injury is mainly caused by oxidative stress and inflammatory reaction caused by the deposition of uric acid and uric acid crystals in the kidney.A sharp increase in uric acid levels in a short period of time can lead to UANs, while long-term uric acid levels rise.
【作者单位】：复旦大学附属中山医院肾脏科;
【分类号】：R692

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