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血糖对前列腺穿刺活检患者的影响

发布时间:2018-04-13 23:16

  本文选题:血糖 + 前列腺癌 ; 参考:《苏州大学》2014年硕士论文


【摘要】:目的1、探讨前列腺穿刺活检患者的血糖对前列腺癌检出率和Gleason评分的影响。2、探讨前列腺穿刺活检中前列腺癌患者的血糖与Gleason评分、前列腺特异性抗原(tPSA)、体重指数(BMI)、前列腺总体积(TPV)和年龄等因素之间的相互关系。 方法前瞻性收集2010年2月~2013年4月在苏州大学附属第一医院初次行经直肠前列腺穿刺活检患者的血糖、Gleason评分、tPSA、BMI、TPV、年龄等临床资料,所有患者以血糖6.1mmol/L为界分成两组,采用2检验比较高血糖组和正常血糖组前列腺癌检出率和Gleason评分的差异,,运用Spearman等级相关分析血糖与Gleason评分、tPSA、BMI、TPV、年龄等之间的相互关系。 结果452例前列腺穿刺活检患者中,前列腺癌183例,高血糖组和正常血糖组前列腺癌检出率分别为43.00%和39.77%,差异没有统计学显著意义;高血糖组前列腺癌患者中低Gleason评分者(Gleason评分<7分)占20.93%,明显高于正常血糖组前列腺癌的6.43%(P<0.05),高血糖组前列腺癌患者中低Gleason评分的优势比(OR)为3.85(95%CI:1.42-10.40),高Gleason评分(Gleason评分≥7分)的OR为0.26(95%CI:0.10-0.70)。Spearman等级相关分析显示前列腺癌患者的血糖值与Gleason评分呈负相关(r=-0.256,P<0.05),与BMI呈正相关(r=0.267,P<0.05),与年龄、TPV、tPSA和I-PSS评分相关性无统计学意义(P>0.05)。 结论前列腺穿刺活检患者的血糖对前列腺癌检出率没有明显影响。高血糖组前列腺癌患者中低Gleason评分的OR明显高于高Gleason评分的OR,血糖是影响前列腺穿刺活检患者前列腺癌Gleason评分的一个独立因素。
[Abstract]:Objective : To investigate the effects of blood glucose on the detection rate of prostate cancer and Gleason score in patients with prostate biopsy , and investigate the correlation between the blood glucose and Gleason score , prostate specific antigen ( tPSA ) , body mass index ( BMI ) , total prostate volume ( TPV ) and age in prostate biopsy .

Methods The blood glucose , Gleason score , tPSA , BMI , TPV and age were prospectively collected from February 2010 to April 2013 at the First Affiliated Hospital of Suzhou University . All patients were divided into two groups with blood glucose of 6.1 mmol / L . The correlation between blood glucose and Gleason score , tPSA , BMI , TPV , age and the like was analyzed .

Results Among the 452 cases of prostate biopsy , 183 cases of prostate cancer , 43 . 00 % and 39.77 % of normal blood sugar group were detected , and the difference was not statistically significant .
The odds ratio ( OR ) was 3.85 ( 95 % CI : 1.42 - 10.40 ) and Gleason score ( Gleason score 鈮

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