MR动态增强定量参数对鉴别前列腺良恶性病变的价值及与血清PSA的相关性

发布时间：2018-04-16 08:05

本文选题：前列腺病变 + 动态增强　；参考：《中国医学计算机成像杂志》2017年03期

【摘要】：目的:探讨MR动态增强(DCE-MRI)定量测量在前列腺良、恶性病变鉴别诊断中的价值以及定量参数值与血清特异性抗原(PSA)的相关性。方法:回顾性分析75例行DCE-MRI扫描且经病理穿刺活检证实的前列腺疾病患者,其中前列腺癌(PCa)30例,前列腺增生(BPH)45例。测量两组病变感兴趣区(ROI)定量参数K~(trans)、K_(ep)、V_e值,采取独立样本t检验进分析比较,并分析三组数值与PSA的关系。结果:K~(trans)及K_(ep)值在PCa和BPH组间差异均有统计学差异(P0.01),V_e值无统计学意义(P=0.72);PCa组K~(trans)、K_(ep)值与血清PSA值呈正相关(r值分别为0.49、0.63,P0.05),V_e值与血清PSA值无相关性(r=0.78,P0.05);BPH组K~(trans)、K_(ep)、V_e值与血清PSA值均无相关性(r=0.0.36、-0.077、-0.045,P0.05)。结论:定量参数K~(trans)及K_(ep)值对PCa和BPH的鉴别诊断有重要价值,V_e无明显价值,且PCa K~(trans)、K_(ep)值与血清PSA值呈正相关,可为PCa的诊断提供参考。
[Abstract]:Objective: to investigate the value of DCE-MRI quantitative measurement in differential diagnosis of benign and malignant prostate lesions and the correlation between quantitative parameters and serum specific antigen (PSA).Methods: 75 cases of prostatic diseases confirmed by DCE-MRI scan and pathological biopsy were retrospectively analyzed, including 30 cases of prostate cancer and 45 cases of benign prostatic hyperplasia.The quantitative parameters of the two groups were measured, and the correlation between the three groups of values and PSA was analyzed by t-test.Conclusion: there is no significant value in the differential diagnosis of PCa and BPH, and the value of serum PSA is positively correlated with the value of PCa. It can be used as a reference for the diagnosis of PCa.
【作者单位】：上海市交通大学医学院附属新华医院崇明分院放射科;
【基金】：卫计委科研基金项目No.201540148 上海市崇明县科委启明星项目基金No.CQYL2014-09 上海交通大学医学院科技基金No.14XJ22013~~
【分类号】：R445.2;R737.25

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